The resistance mechanisms and treatment strategies of BTK inhibitors in B-cell lymphoma - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34651869/

Bruton's tyrosine kinase inhibitors (BTKi) have revolutionized the treatment of B-cell lymphoma (BCL). These drugs interfere with the mechanisms underlying malignant B-cell pathophysiology, allowing better drug response as well as...

Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34645618/

Better understanding of GBM signalling networks in-vivo would help develop more physiologically relevant ex vivo models to support therapeutic discovery. A "functional proteomics" screen was undertaken to measure the specific...

BTK Inhibitors in Chronic Lymphocytic Leukemia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34599723/

The approval of ibrutinib rapidly led to a paradigm shift in the management of CLL. Randomized trials have now compared ibrutinib to several chemoimmunotherapy approaches, which were in favor of...

Chronic Lymphocytic Leukemia (CLL): Biology and Therapy - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34626359/

Chronic lymphocytic leukemia (CLL), the most common leukemia in the western world, is characterized by the accumulation of monoclonal B-lymphocytes in the bone marrow and lymphoid organs. Signaling via the...

Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34614413/

1 Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. 2 Georgia Cancer...