Targeting of HSP70/HSF1 Axis Abrogates In Vitro Ibrutinib-Resistance in Chronic Lymphocytic Leukemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34771616/
The Btk inhibitor ibrutinib has significantly changed the management of chronic lymphocytic leukemia (CLL) patients. Despite its clinical efficacy, relapses occur, and outcomes after ibrutinib failure are poor. Although BTK...
We suggest an involvement of HSP70/HSF1 axis in controlling resistance to ibrutinib in CLL cells, since their inhibition is effective in inducing in vitro apoptosis in cells from ibrutinib refractory patients. The targeting of HSP70/HSF1 axis could represent a novel rational therapeutic strategy for CLL, also for relapsing patients.
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Leukemia and Lymphoma Connect4yrKey Points • Source: Cancers • Conclusion/Relevance: “In several tumors, HSP70 and HSF1 overexpression is one of the causes of low therapy response, allowing cancer cells to escape apoptosis and survive despite stressing conditions. Show More
Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma - Virchows Archiv
Source : https://link.springer.com/article/10.1007/s00428-021-03228-w
SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that restricts viral replication in infected cells and limits the sensitivity to cytarabine by hydrolysing its active metabolite, as recently shown in acute...
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Leukemia and Lymphoma Connect4yrKey Points • Source: Virchows Archiv • Conclusion/Relevance: “In conclusion, we here report a wide variability in SAMHD1 expression in MCL [mantle cell lymphoma] and a positive correlation to known biological adverse factors such Show More
The Role of BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34744463/
The B cell receptor (BCR) signaling pathway is functional and has critical cell survival implications in B cell malignancies, such as chronic lymphocytic leukemia (CLL). Orally administered small molecule tyrosine...
Update on Novel Therapeutics for Primary CNS Lymphoma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34771535/
Primary central nervous system lymphoma (PCNSL) is a rare lymphoma isolated to the central nervous system or vitreoretinal space. Standard treatment consists of cytotoxic methotrexate-based chemotherapy, with or without radiation....
This review provides a discussion on the challenges in development of targeted therapeutic strategies, an update on recent treatment advances, and offers a look toward ongoing clinical studies.
Phase 1 Clinical Trial Evaluating Safety, Exposure and Pharmacodynamics of BTK Inhibitor Tolebrutinib (PRN2246, SAR442168) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34724345/
Bruton's tyrosine kinase (BTK), expressed in B cells and cells of innate immunity including microglia, is an essential signalling element downstream of the B-cell receptor and Fc-receptors. Tolebrutinib (PRN2246, SAR442168)...