Progressive Multifocal Leukoencephalopathy Among Ibrutinib Treatment In Chronic Lymphocytic Leukemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35037793/
PML is a rare and often fatal demyelinating disease of the central nervous system (CNS) that is exclusively seen in immunocompromised patients and there is no specific agent to treat...
Discussion: PML is a rare and often fatal demyelinating disease of the central nervous system (CNS) that is exclusively seen in immunocompromised patients and there is no specific agent to treat PML. The case discussed here, highlights that the use of ibrutinib in chronic lymphocytic leukemia (CLL) therapy may result in PML.
Arrhythmia Patterns in Patients on Ibrutinib
Source : https://www.frontiersin.org/articles/10.3389/fcvm.2021.792310/full
Introduction: Ibrutinib, a Bruton's tyrosine kinase inhibitor (TKI) used primarily in the treatment of hematologic malignancies, has been associated with increased incidence of atrial fibrillation (AF), with limited data on...
Conclusions: In this large dataset of ambulatory cardiac monitors on patients treated with ibrutinib, we report a high prevalence of atrial and VAs, with a high incidence of treatment interruption secondary to arrhythmias and related symptoms. Further research is warranted to optimize strategies to diagnose, monitor, and manage...
Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35031886/
Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma characterized by poor prognosis. The complexity of MCL pathogenesis arises from aberrant activities of diverse signaling pathways, including BTK, PI3K-AKT-mTOR...
Relevance: Our findings underscore the effectiveness of novel multi-action small molecule inhibitors for potential treatment of MCL.
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors
Source : https://www.sciencedirect.com/science/article/abs/pii/S0960894X22000257?via=ihub
BTK is a tyrosine kinase playing an important role in B cell and myeloid cell functions through B cell receptor (BCR) signaling and Fc receptor (FcR) ...
Conclusion/Relevance: Here we report the design, optimization, and characterization of novel potent and highly selective covalent BTK inhibitors.
Invasive Fungal Infections and Targeted Therapies in Hematological Malignancies
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706272/
Marcio Nucci, Academic Editor The use of targeted biologic therapies for hematological malignancies has greatly expanded in recent years. These agents act upon specific molecular pathways in order to target...