Human T-bet+ B cell development is associated with BTK activity and suppressed by evobrutinib
Source : https://insight.jci.org/articles/view/160909
Recent clinical trials show promising results for the next-generation Bruton's tyrosine kinase (BTK) inhibitor evobrutinib in the treatment of multiple sclerosis (MS). BTK has a central role in signaling pathways...
Conclusion/Relevance: These findings demonstrate a functional link between BTK activity and disease-relevant B cells and offer valuable insights into how next-generation BTK inhibitors could modulate the clinical course in MS patients.
Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35845214/
All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK-1026. The mechanism underlying increased...
Conclusion: As MK-1026 showed less off-target effects and only affected activation of isolated platelets, it might be promising for future treatment.
Practical management of chronic lymphocytic leukemia with acalabrutinib
Source : https://www.tandfonline.com/doi/full/10.1080/10428194.2022.2098289
Abstract Abstract Treatment of chronic lymphocytic leukemia (CLL) has been transformed in the past two decades. The introduction of targeted therapies has improved patient outcomes and the deliverability of effective...
Conclusion: Acalabrutinib represents a well-tolerated and effective alternative to ibrutinib in the management of CLL.
Role of high acquisition flow cytometry in the detection of marrow involvement in patients with extramedullary B cell non-Hodgkins lymphoma: a comparison with marrow aspirate cytology, trephine biopsy, and PET
Source : https://www.tandfonline.com/doi/abs/10.1080/10428194.2022.2092858?journalCode=ilal20
Abstract Detection of marrow infiltration is crucial in extramedullary B cell non-Hodgkin lymphoma (B-NHL). We studied the efficiency of high acquisition flow cytometry (FCM) in detecting marrow involvement in B-NHL...
Conclusion: This study shows that a combination of PET and FCM with high event acquisition is the best way for assessing marrow involvement in B-NHL cases.
Estrogen Receptor β (ESR2) Transcriptome and Chromatin Binding in a Mantle Cell Lymphoma Tumor Model Reveal the Tumor-Suppressing Mechanisms of Estrogens - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35804870/
Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma with one of the highest male-to-female incidence ratios. The reason for this is not clear, but epidemiological as well as experimental data...
Conclusion: The results clarify the mechanisms by which estrogens, via ESR2, impair MCL tumor progression and provide a possible explanation for the sex-dependent difference in incidence. Furthermore, targeting ESR2 with a selective agonist may be an additional option when considering the treatment of both ibrutinib-sensitive and -resistant MCL...