Menin inhibitors in pediatric acute leukemia: a comprehensive review and recommendations to accelerate progress in collaboration with adult leukemia and the international community - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39179671/
Aberrant expression of HOX and MEIS1 family genes, as seen in KMT2A-rearranged, NUP98-rearranged, or NPM1-mutated leukemias leads to arrested differentiation and leukemia development. HOX family genes are essential gatekeepers of...
Aberrant HOX and MEIS1 gene expression in specific leukemias leads to differentiation arrest. Menin inhibitors show promise in treating these conditions, prompting collaborative international efforts for clinical trials in pediatric populations.
Cost-effectiveness of blinatumomab for the treatment of B‑precursor acute lymphoblastic leukemia pediatric patients with high‑risk first‑relapse in Mexico
Source : https://pubmed.ncbi.nlm.nih.gov/39214018/
Blinatumomab was associated with greater benefit in terms of OS and EFS relative to SC. Probabilistic, deterministic, and scenario analyses indicate that blinatumomab represents the best value for money. Therefore,...
Blinatumomab demonstrated significant cost-effectiveness over standard chemotherapy for pediatric high-risk first-relapsed B-ALL, yielding an incremental cost-effectiveness ratio of $121,526 MXN per life-year gained.
Aggressive NK-cell Leukemia: A Case Report and Literature Review
Source : https://pubmed.ncbi.nlm.nih.gov/38330588/
ANKL is rare in the world, and the disease is aggressive, so it is necessary to diagnose early and intervene timely. Bone marrow smear, flow cytometer and Q-mNGS are helpful...
ANKL is an aggressive disease requiring early diagnosis and timely intervention. Comprehensive treatment approaches, including supportive care and allo-HSCT, are crucial for improving patient outcomes. More data is needed for guidance.
Post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation: a case report, meta-analysis, and systematic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39244586/
This case highlighted the urgent need for effective, low-toxic treatment regimens for CNS-PTLD. Our meta-analysis suggested that rituximab combined with EBV-CTLs/DLI could be a favorable strategy for the management of...
This case highlighted the urgent need for effective, low-toxic treatment regimens for CNS-PTLD. Our meta-analysis suggested that rituximab combined with EBV-CTLs/DLI could be a favorable strategy for the management of PTLD after allo-HSCT.
Monomorphic T-cell post-transplant lymphoproliferative disorder with features of HHV8-negative primary effusion lymphoma: an autopsy case and review of the literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38780761/
A 67-year-old man underwent renal transplantation in his twenties. He developed refractory pleural effusion, with many large lymphocytes with severe atypia and mitosis in the effusion, indicating malignant lymphoma. He...
This case highlights a rare monomorphic T-cell post-transplant lymphoproliferative disorder resembling HHV8-negative primary effusion lymphoma, suggesting an association with early renal transplantation and CD30 tumor expression. Further investigation is needed.