Bruton tyrosine kinase inhibitors preserve anti-CD19 chimeric antigen receptor T-cell functionality and reprogram tumor micro-environment in B-cell lymphoma
Source : https://www.isct-cytotherapy.org/article/S1465-3249(23)00066-X/fulltext
Combination therapy is being actively explored to improve the efficacy and safety of anti-CD19 chimeric antigen receptor T-cell (CART19) therapy, among which Bruton tyrosine kinase inhibitors (BTKIs) are highly expected....
Conclusions: Our data revealed that BTKIs preserved T-cell and CART19 functionality under persistent antigen exposure and further demonstrated that BTKI administration was a potential strategy for mitigating cytokine release syndrome after CART19 treatment. Our study lays the experimental foundation for the rational application of BTKIs...
USP14 promotes the malignant progression and ibrutinib resistance of mantle cell lymphoma by stabilizing XPO1
Source : https://www.medsci.org/v20p0616.htm
Int J Med Sci 2023; 20(5):616-626. doi:10.7150/ijms.80467 This issue Cite Research Paper Ye Zhang 1 , Peng Lu 2, Shenhe Jin 1, Jin Zhang 1, Yan Zhou 1 1. Department...
Conclusion: USP14 can promote the malignant progression and ibrutinib sensitivity of MCL by stabilizing XPO1.
Therapeutic Targets in Myelodysplastic Neoplasms: Beyond Hypomethylating Agents - Current Hematologic Malignancy Reports
Source : https://link.springer.com/article/10.1007/s11899-023-00693-9
Purpose of Review To discuss novel targeted therapies under investigation for treatment of myelodysplastic neoplasms (MDS). Recent Findings Over the last few years, results of phase 3 trials assessing novel...
Relevance: In this review, we focus on the current management strategies and novel therapies in development for treatment of high-risk MDS.
Clinicopathological and molecular genetic characteristics of primary gastric follicular lymphoma☆,☆☆,☆☆☆
Source : https://www.sciencedirect.com/science/article/abs/pii/S0046817723000862?via=ihub
Available online 11 April 2023 Author links open overlay panel, , , , , , , Young Hyeh Ko g h Show more Primary gastric follicular lymphomas (FLs) have been...
Conclusion: Primary gastric FL is characterized by a low-grade neoplasm with infrequent BCL2 rearrangement. After resection of the lesion, additional treatment such as radiation therapy or chemotherapy is required as there is a possibility of recurrence.
A Rare B-Myeloid Conversion of Follicular Lymphoma into Clonally Related Acute Myeloid Leukemia: A Case Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36983884/
Follicular lymphoma (FL) is a highly prevalent indolent lymphoma, and the risk of histological transformation is approximately 2-3% per year. Transformation of FL generally occurs in the same lineage (B...
Summary: B-myeloid conversion of follicular lymphoma into clonally related AML is extremely rare. Coactivation of NF-κB and Notch signaling is sufficient to lead B-myeloid conversion. Patients with this transformation are associated with an aggressive clinical course and poor prognosis. The m7-FLIPI can improve the prognosis of patients with...