The five-day meeting was held at McCormick Place in Chicago from June 2 to 6, 2023. Click to access a summary of the program highlights from our team of analysts.
Source : https://pubmed.ncbi.nlm.nih.gov/37264757/
Our study presents the most promising first-line treatment strategy for transplant-ineligible MCL patients in terms of PFS and OS, which provides innovative treatment strategy for MCL treatment.
Conclusions: Our study presents the most promising first-line treatment strategy for transplant-ineligible MCL patients in terms of PFS and OS, which provides innovative treatment strategy for MCL treatment.
The 2023 American Society of Clinical Oncology (ASCO) annual meeting spans five days and features the latest and greatest practice-changing research on diagnosing and treating all types of cancer. This year’s meeting, which is taking place at McCormick Place in Chicago from June 2 to 6, boasts more than 2,900 abstracts and 2,600-plus poster presentations and has garnered its share of headlines in the consumer and trade press.
Access details from this year's annual meeting.
Source : https://pubmed.ncbi.nlm.nih.gov/37267517/
Mantle cell lymphoma (MCL) is an incurable B-cell malignancy with overall poor prognosis particularly for patients that progress on targeted therapies. Novel more durable treatment options are needed for patients...
Conclusions/Relevance: We propose pharmacologic inhibition of PRMT5 for patients with relapsed/refractory MCL and identify MTAP/CDKN2A deletion and WT TP53 as biomarkers that predict a favorable response. Selective targeting of PRMT5 has significant activity in preclinical models of MCL and warrants further investigation...
Source : https://pubmed.ncbi.nlm.nih.gov/37242447/
In spite of the increasing number of biologics license applications, the development of covalent inhibitors is still a growing field within drug discovery. The successful approval of some covalent protein...
Relevance: The aim of this review is to highlight the current state of covalent inhibitor development, including a short historical overview and some examples of applications of PROTAC technologies and treatment of the SARS-CoV-2 virus.