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Novel agents in relapsed/refractory diffuse large B-cell lymphoma - PubMed

Novel agents in relapsed/refractory diffuse large B-cell lymphoma - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37294966/

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Conclusions/Relevance: In this chapter we review updated data supporting the use of the approved agents and discuss other emerging novel therapies for patients with R/R DLBCL.

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2yr
Tackling the dysregulated immune-checkpoints in classical Hodgkin lymphoma: bidirectional regulations between the microenvironment and Hodgkin/Reed-Sternberg cells

Tackling the dysregulated immune-checkpoints in classical Hodgkin lymphoma: bidirectional regulations between the microenvironment and Hodgkin/Reed-Sternberg cells

Source : https://www.frontiersin.org/articles/10.3389/fonc.2023.1203470/full

Immune evasion is considered one of the modern hallmarks of cancer and is a key element in the pathogenesis of classical Hodgkin Lymphoma (cHL). This haematological cancer achieves effective avoidance...

Conclusions/Relevance: In this review, we will discuss the physiology of the PD-1/PD-L axis and how cHL is able to exploit a plethora of different molecular mechanisms to build an immunosuppressive microenvironment and achieve optimal immune evasion. We will then discuss the success obtained by checkpoint inhibitors (CPI) in treating cHL,...

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2yr
Blastoid and Pleomorphic Mantle Cell Lymphoma Demonstrate... : The American Journal of Surgical Pathology

Blastoid and Pleomorphic Mantle Cell Lymphoma Demonstrate... : The American Journal of Surgical Pathology

Source : https://journals.lww.com/ajsp/Fulltext/9900/Blastoid_and_Pleomorphic_Mantle_Cell_Lymphoma.177.aspx

ageJ) and we assessed mutational and gene expression profiles. The chromatin pattern of lymphoma cells was assessed quantitatively by the pixel value. Cases of B-MCL showed a greater median pixel...

Summary: These data suggest biological differences between B-MCL and P-MCL cases justifying their separate designation when possible.

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2yr
Mantle cell lymphoma-Update on molecular biology, prognostication and treatment approaches - PubMed

Mantle cell lymphoma-Update on molecular biology, prognostication and treatment approaches - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37294961/

Mantle cell lymphoma (MCL) is clinically characterized by its heterogenous behavior with courses ranging from indolent cases that do not require therapy for years to highly aggressive MCL with very...

Conclusions/Relevance: This review summarizes the current knowledge and standard of care regarding biology and clinical management of MCL, highlighting the implementation of new therapeutic approaches especially targeting the immune system.

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2yr
Conference Coverage of the European Hematology Association Hybrid Congress

The European Hematology Association hosts its annual meeting every June. This year, the Hybrid Congress is taking place in Frankfurt, Germany, from June 8 to 11.

Click to access summaries on some of the many presentations that caught the eye of our team of analysts.