CD19 CAR T-cell therapy and prophylactic anakinra in relapsed or refractory lymphoma: phase 2 trial interim results - Nature Medicine
Source : https://www.nature.com/articles/s41591-023-02404-6
In preclinical models, anakinra, an IL-1 receptor antagonist (IL-1Ra), reduced immune effector cell-associated neurotoxicity syndrome (ICANS) without compromising anti-CD19 chimeric antigen receptor (CAR) T-cell efficacy. We initiated a phase 2...
Conclusions/Relevance: These initial results show that prophylactic anakinra resulted in a low incidence of ICANS in patients with lymphoma receiving anti-CD19 CAR T-cell therapy and support further study of anakinra in immune-related neurotoxicity syndromes.
Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies
Source : https://www.sciencedirect.com/science/article/pii/S2352304222001751?via=ihub
Sterile α motif and histidine/aspartic acid domain containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate (dNTPs) triphosphohydrolase that ca...
Conclusion: SAMHD1 plays a vital role in the development, therapeutic resistance, and prognosis of hematological malignancies. To guide clinical treatment, in the future, SAMHD1 may be used as a novel risk stratification biomarker for hematological malignancies, such as MCL, AML, and cHL. In addition, the development of SAMHD1-specific...
Soluble CD163 predicts outcome in both chemoimmunotherapy and targeted therapy-treated mantle cell lymphoma
Key Points. High level of the soluble macrophage marker CD163 is associated with shorter progression-free and overall survival in mantle cell lymphomaSoluble CD
Conclusions/Relevance: Here, high sCD163 was associated with both shorter PFS (HR 3.48 95% CI: 1.42-8.54) and shorter OS (HR 4.33 95% CI: 1.32-14.2), showing that high levels of the M2 macrophage marker sCD163 is an independent negative prognostic factor in MCL, both in the chemoimmunotherapy and ibrutinib/lenalidomide era. In addition, low...
Unveiling the Prognostic Significance of BCL6+/CD10+ Mantle Cell Lymphoma: Meta-Analysis of Individual Patients and Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37373354/
Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma (NHL) characterized by a hallmark translocation of t (11; 14). CD10 negativity has been used to differentiate MCL from other...
Conclusions/Relevance: Targeted therapies against BCL6 may offer potential therapeutic options for managing MCL with aberrant immunophenotypes.
A Pancreatic Collision Tumor Comprising Mantle Cell Lymphoma and Adenocarcinoma: A Case Report and Literature Review
Source : https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_1937-23/_article
A collision tumor is a rare clinical condition where two different tumors occur synchronically within a lesion. Pancreatic collision tumors with mantl ...
Relevance: A collision tumor is a rare clinical condition where two different tumors occur synchronically within a lesion. Pancreatic collision tumors with mantle cell lymphoma (MCL) are extremely rare and have only been reported in one case to date.