Infectious Complications During Monoclonal Antibodies Treatments and Cell Therapies in Acute Lymphoblastic Leukemia
Source : https://link.springer.com/article/10.1007/s10238-023-01000-9
Infections represent one of the most frequent complications during the treatment of patients with Acute Lymphoblastic Leukemia (ALL): of these, almost half develop an infectious event in the majority of...
In this review, we examined studies published in the literature over the past 12 years and described the infectious complications of therapy with Blinatumomab, Inotuzumab, Rituximab and CAR-T in adult and pediatric patients with ALL. Infections are less frequent than in traditional chemotherapy treatment with vincristine, corticosteroids and...
Incorporating Mutations and Bone Marrow Fibrosis into the Revised International Prognostic Scoring System in Myelodysplastic Syndromes
Source : https://pubmed.ncbi.nlm.nih.gov/37865969/
The independent prognostic significance of bone marrow fibrosis (BMF) in myelodysplastic syndromes (MDS) is challenged under currently molecular prognostic models. In this study, the clinical and genetic data from 438...
BMF was an independent significant prognostic factor for MDS, and adding BMF into the IPSS-R improved its predictive capability.
Regulation and Signaling Pathways in Cancer Stem Cells: Implications for Targeted Therapy for Cancer
Source : https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-023-01877-w
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their behavior is...
This review outlines the origin and biological characteristics of CSCs, explores the regulatory networks governing CSCs, discusses the signaling pathways implicated in these networks, and investigates the influential factors contributing to therapy resistance in CSCs
A Novel Peptide That Disrupts the Lck-IP3R Protein-Protein Interaction Induces Widespread Cell Death in Leukemia and Lymphoma
A Novel Peptide that Disrupts the Lck-IP3R Protein-Protein Interaction Induces Widespread Cell Death in Leukemia and Lymphoma.
These data show that a peptide designed to disrupt the Lck-IP3R PPI has a wide range of preclinical activity in leukemia and lymphoma.
Aging and Age-Related Epigenetic Drift in the Pathogenesis of Leukemia and Lymphomas: New Therapeutic Targets
Source : https://pubmed.ncbi.nlm.nih.gov/37830606/
One of the traits of cancer cells is abnormal DNA methylation patterns. The idea that age-related epigenetic changes may partially explain the increased risk of cancer in the elderly is...
Understanding these changes will open up promising pathways for therapies against age-related disorders because epigenetic mechanisms are reversible. Development of high-throughput epigenome mapping technologies will make it possible to identify the epigenomic identity card of every hematological disease as well as every patient, opening up...