Association of MicroRNA Polymorphisms With Toxicities Induced by Methotrexate in Children With Acute Lymphoblastic Leukemia
Source : https://www.mdpi.com/2038-8330/15/4/65
Methotrexate (MTX), a structurally related substance to folic acid, is an important chemotherapeutic agent used for decades in the treatment of pediatric acute lymphoblastic leukemia (ALL) and other types of...
A Pilot Randomized Study for Optimal Red Cell Transfusion in Acute Myeloid Leukemia Patients With Intensive Chemotherapy
Source : https://www.bloodtransfusion.it/bt/article/view/482
Although blood transfusion is fundamental throughout the course of hematologic malignancies, acute myeloid leukemia (AML) patients requiring intensive chemotherapy are left at the edges of patient blood management programs because...
This study demonstrated the feasibility for restrictive RBC transfusion in patients with AML undergoing chemotherapy, regardless of its intensity.
Cauda Equina Syndrome in a Patient With Human Immunodeficiency Virus and Secondary Central Nervous System Lymphoma: a Case Report
Source : https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-023-04212-5
Background Secondary central nervous system lymphoma (SCNSL) is a known complication of immunocompromised patients with most cases involving the brain parenchyma. Reports of cauda equina syndrome (CES) caused by SCNSL...
CES should be considered in at-risk patients especially those presenting with abnormal neurological findings. Prompt recognition may prevent permanent neurological injury and obviate the need for more invasive therapeutic interventions.
Prevalence of Symptoms in Children With Acute Lymphoblastic Leukaemia: a Systematic Review and Meta-Analysis
Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-023-11581-z
Background Children with acute lymphoblastic leukaemia (ALL) experience multiple symptoms that occur in complicated patterns and negatively affect patient outcomes. To date, no systematic review has been performed on the...
Symptoms remain highly prevalent in paediatric patients with ALL, which provides support for the need for symptom assessment in the clinical setting.
Mechanisms of Resistance to Chimeric Antigen Receptor-T Cells in Haematological Malignancies
Source : https://www.nature.com/articles/s41573-023-00807-1
Chimeric antigen receptor (CAR)-T cells have recently emerged as a powerful therapeutic approach for the treatment of patients with chemotherapy-refractory or relapsed blood cancers, including acute lymphoblastic leukaemia, diffuse large...
We discuss current research strategies to overcome multiple resistance mechanisms, including optimization of the CAR design, improvement of in vivo T cell function and persistence, modulation of the immunosuppressive tumour microenvironment and synergistic combination strategies.