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Expression of Interferon Regulatory Factor Family and Its Prognostic Value in Acute Myeloid Leukemia

Expression of Interferon Regulatory Factor Family and Its Prognostic Value in Acute Myeloid Leukemia

Source : https://www.futuremedicine.com/doi/10.2217/fon-2023-0443

The expression level of IRF1/2/4/5/7-9 in patients with AML was upregulated, whereas IRF3/6 expression was downregulated. High IRF1/7/9 expression indicated a worse OS rate.

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2yr
American Society of Hematology Annual Meeting and Exposition

The 65th American Society of Hematology (ASH) Annual Meeting and Exposition took place from Dec. 9 to 12, 2023, in San Diego. 

Considered the premier event in malignant and nonmalignant hematology, the four-day meeting of physicians and scientists who study and treat blood diseases featured potentially practice-changing news and treatment updates across the full spectrum of blood disorders. With more than 3,000 abstracts presented orally and via poster presentation, one of the main goals of the ASH annual meeting each year is to present the top data in all areas of hematology.

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2yr
Overcoming Resistance in Chronic Lymphocytic Leukemia - Maybe Less Is More?

Overcoming Resistance in Chronic Lymphocytic Leukemia - Maybe Less Is More?

Source : https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-23-2872/731539

Acquired mutations in BTK, PLCG2 and BCL2 are associated with resistance to continuous targeted agent therapy in chronic lymphocytic leukemia (CLL). Here, we discuss new evidence that limiting the duration...

New evidence suggests that limiting the duration of CLL therapy may prevent the evolution of such resistance mutations, potentially facilitating effective re-treatment strategies.

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2yr
Testicular Involvement in Mantle Cell Lymphoma: an Analysis of 16 Patients

Testicular Involvement in Mantle Cell Lymphoma: an Analysis of 16 Patients

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694562/

Mantle cell lymphoma (MCL) with testicular involvement is a rare presentation and only a few cases have been described in the literature. We present a case of MCL with testicular...

These data suggest that testicular MCL is more likely to present with aggressive features including blastoid/pleomorphic morphology, high Ki-67 proliferative index, and CNS involvement.

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2yr
American Society of Hematology Annual Meeting and Exposition

The 65th American Society of Hematology (ASH) Annual Meeting and Exposition is taking place from Dec. 9 to 12, 2023, in San Diego. 

The four-day meeting brings together physicians and scientists who treat and study blood diseases so they can learn about the latest and greatest ways to diagnose and treat diseases across the spectrum of malignant and nonmalignant hematology.