Engineering the Best Transplant Outcome for High-Risk Acute Myeloid Leukemia: the Donor, the Graft and Beyond
Source : https://www.isct-cytotherapy.org/article/S1465-3249(23)01103-9/fulltext
Allogeneic hemopoietic cell transplantation remains the goal of therapy for high-risk acute myeloid leukemia (AML). However, treatment failure in the form of leukemia relapse or severe graft-versus-host disease remains a...
This review summarizes the literature regarding the identification of high risk in AML, treatment approaches before transplant, optimal transplant platforms and measures that may be taken after transplant to ideally prevent, or, if need be, treat AML relapse.
A Challenging Diagnosis of Merkel Cell Carcinoma Occurring in the Lymph Nodes and Skin of a Patient With Mantle Cell Lymphoma: a Case Report
Source : https://medicaljournalssweden.se/actadv/article/view/12328/39315
Return to Article Details A Challenging Diagnosis of Merkel Cell Carcinoma Occurring in the Lymph Nodes and Skin of a Patient with Mantle Cell Lymphoma: A Case Report
The unusual presentation of metastatic MCC of unknown primary site co-occurring in a lymph node with MCL may have posed a diagnostic challenge on histology alone. However, use of immunohistochemistry and ancillary studies, including flow cytometry and cytogenetics, confirmed the concurrent diagnoses.
Role of FDG PET/CT in Patients With Lymphoma Treated With CAR T-Cell Therapy: Current Concepts
Source : https://pubmed.ncbi.nlm.nih.gov/38054958/
Chimeric antigen receptor (CAR) T-cell therapy is a cellular therapy in which the patient's T cells are enhanced to recognize and bind to specific tumor antigens.
This article reviews current concepts in CAR T-cell therapy in patients with lymphoma, emphasizing the critical role of FDG PET/CT before and after therapy.
Post-PICU Cognitive and Psychological Outcomes in Children Receiving Treatments for Acute Lymphoblastic Leukemia
All patients in this study (n = 296; ages 3-21) were treated for ALL on the St. Jude Total Therapy 16 clinical trial (NCT00549848) from 2007 to 2017. Of these,...
Children with ALL who had a PICU admission experienced statistically significantly lower functioning compared to normative samples in several areas of cognitive functioning, daily living skills, and internalizing problems.
Severe Infections Requiring Intensive Care Unit Admission in Patients Receiving Ibrutinib for Hematological Malignancies: a Groupe De Recherche Respiratoire En Réanimation Onco-Hématologique (GRRR-OH) Study
Source : https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-023-01219-5
Background In the last decade, Ibrutinib has become the standard of care in the treatment of several lymphoproliferative diseases such as chronic lymphocytic leukemia (CLL) and several non-Hodgkin lymphoma. Beyond...
Severe infections requiring ICU admission were associated with a dismal prognosis, with over 50% of mortality at day 90, mostly impacted by initial organ dysfunctions.