Romidepsin Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Versus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Final Analysis of the Ro-CHOP Trial
Source : https://pubmed.ncbi.nlm.nih.gov/38364196/
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or...
Within the limits of highly heterogeneous second-line treatments, no specific regimen seemed to provide superior disease control.
Ponatinib demonstrated a superior rate of minimal residual disease–negative complete remission at the end of induction versus imatinib when combined with reduced-intensity chemotherapy.
Comparison of Comorbidity Models Within a Population-Based Cohort of Older Adults With Non-Hodgkin Lymphoma
Source : https://pubmed.ncbi.nlm.nih.gov/38684043/
The optimal measure of comorbidity in NHL is unknown. Here, we demonstrate that the three-category TRES and five-category NHL-5 scores perform as well as the 14-16 category CCI and NCI...
Researchers found similar associations with OS and lymphoma-specific survival, which was confirmed in sensitivity analyses by non-Hodgkin lymphoma subtypes.
Clonal Hematopoiesis and Therapy-Related Myeloid Neoplasms After Autologous Transplant for Hodgkin Lymphoma
Source : https://pubmed.ncbi.nlm.nih.gov/38635938/
The presence of TP53 and/or PPM1D mutations in the PBSC product increases the risk of post-aPBSCT t-MN and nonrelapse mortality among patients with HL and may support alternative therapeutic strategies.
All patients with TP53 mutations in the peripheral blood stem cell transplantation product developed therapy-related myeloid neoplasm, whereas none of the patients with DNMT3A mutations alone did.

