Mechanisms Underlying the Development of Murine T-Cell Lymphoblastic Lymphoma/Leukemia Induced by Total-Body Irradiation
Source : https://pubmed.ncbi.nlm.nih.gov/38927929/
Exposure to ionizing radiation is associated with an increased risk of hematologic malignancies in myeloid and lymphoid lineages in humans and experimental mice. Given that substantial evidence links radiation exposure...
Radiation-induced thymic lymphoma in mice, driven by Notch signaling, serves as a valuable model for studying hematologic malignancies. Understanding its mechanisms is crucial for insights into cancer initiation and progression in response to radiation exposure.
Efficacy and safety of new-generation Bruton tyrosine kinase inhibitors in chronic lymphocytic leukemia/small lymphocytic lymphoma: a systematic review and meta-analysis
Source : https://pubmed.ncbi.nlm.nih.gov/37843620/
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a type of mature B lymphocyte clonal proliferative tumor with a specific immunophenotype. Bruton tyrosine kinase inhibitors (BTKi) have been approved for the...
The systematic review concluded that new-generation BTK inhibitors (BTKi) show high efficacy (ORR 92%, CR 10%) in CLL/SLL, especially in younger, treatment-naive patients and in combination therapies. Acalabrutinib and zanubrutinib have varying benefits and tolerances, with cytopenia and hypertension being common grade ≥ 3 AEs.
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Source : https://pubmed.ncbi.nlm.nih.gov/38824603/
Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously challenging to treat and outcomes are typically poor. Over the past two decades, clinical prognostic...
The advancements in PTCL molecular understanding are shaping personalized treatment strategies and targeted therapies, emphasizing the need for ongoing research to improve patient outcomes with novel biologics and CAR-T therapies.
Escape from T-cell-targeting immunotherapies in acute myeloid leukemia
Source : https://pubmed.ncbi.nlm.nih.gov/37467496/
Single-cell and spatial multimodal technologies have propelled discoveries of the solid tumor microenvironment (TME) molecular features and their correlation with clinical response and resistance to immunotherapy. Computational tools are incessantly...
Integrating multimodal omics technologies with prognostic markers and stratifying AML patients for tailored immunotherapies offers promising avenues to overcome immune resistance, improve outcomes, and personalize treatment strategies in AML.
Can O-GIcNAc Transferase (OGT) Complex Be Used as a Target for the Treatment of Hematological Malignancies?
Source : https://pubmed.ncbi.nlm.nih.gov/38931332/
The circulatory system is a closed conduit system throughout the body and consists of two parts as follows: the cardiovascular system and the lymphatic system. Hematological malignancies usually grow and...
Cancer development and progression are often accompanied by the overexpression of OGT and abnormal overall O-GlcNAcylation, which may drive the life course of cancer cell survival, proliferation, metastasis, and invasion. In cells, OGT is able to assemble with a variety of proteins to form complexes that are involved in the regulation of...