Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34699592/

1 City of Hope Medical Center, Duarte, California, United States. 2 Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States. 3 UPMC, Pittsburgh, Pennsylvania, United States. 4 University of Utah,...

Multiple myeloma: Detection of free monoclonal light chains by modified immunofixation electrophoresis with antisera against free light chains - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34703870/

Modified serum immunofixation electrophoresis has been shown to detect low levels of monoclonal free light chains at a sensitivity suitable for the method to be used in detecting minimal residual...

VpreB Surrogate Light Chain Expression in B-Lineage ALL: A Report from the Children's Oncology Group - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34662891/

Immunotherapies directed against B-cell surface markers have been a common developmental strategy to treat B-cell malignancies. The IgH surrogate light chain (SLC), comprised of the VpreB1 (CD179a) and Lamda5 (CD179b)...

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34669156/

T-cell acute lymphoblastic leukemia (T-ALL) is one of the most dangerous hematological malignancies, with high tumor heterogeneity and poor prognosis. More than 60% of T-ALL patients carry NOTCH1 gene mutations,...

An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as children with ALL - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34662896/

Pediatric regimens have improved outcomes in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL). However, results remain inferior to children with ALL. The ALLG ALL06 study (anzctr.org.au/ACTRN12611000814976) was designed...