A randomized, phase II trial of adjuvant immunotherapy with durable TKI-free survival in patients with chronic phase CML - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34768161/
doi: 10.1016/j.leukres.2021.106737. Online ahead of print. 1 Hematologic Malignancies and Bone Marrow Transplantation Program, Department of Oncology, Johns Hopkins University School of MedIcine, Baltimore, MD, United States. Electronic address: [email protected]....
Adjuvant IFN led to durable TFRs with limited prior TKI exposure with comparable success to prior discontinuation trials, but many patients stopped IFN early.
Liquid Biopsy to Detect Minimal Residual Disease: Methodology and Impact - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34771526/
One reason why some patients experience recurrent disease after a curative-intent treatment might be the persistence of residual tumor cells, called minimal residual disease (MRD). MRD cannot be identified by...
In this review, we are discussing the different methodologies used and investigated to detect MRD in solid cancers, their respective potentials and issues, and the clinical impacts that MRD detection will have on the management of cancer patients.
Molecular Minimal Residual Disease Detection in Acute Myeloid Leukemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34771594/
Initial induction chemotherapy to eradicate the bulk of acute myeloid leukemia (AML) cells results in complete remission (CR) in the majority of patients. However, leukemic cells persisting in the bone...
Droplet Digital PCR for BCR-ABL1 Monitoring in Diagnostic Routine: Ready to Start? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34771634/
BCR-ABL1 mRNA levels represent the key molecular marker for the evaluation of minimal residual disease (MRD) in chronic myeloid leukemia (CML) patients and real-time quantitative PCR (RT-qPCR) is currently the...
Our results show that ddPCR has a good agreement with RT-qPCR, but it is more precise to quantify BCR-ABL1 transcript levels. Furthermore, we did not find differences between duplicate or quadruplicate analysis in terms of BCR-ABL1% IS values. Droplet digital PCR could be confidently introduced into the diagnostic routine as a complement to the...
Multiparametric Flow Cytometry for MRD Monitoring in Hematologic Malignancies: Clinical Applications and New Challenges
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470441/
Andrei Tchirkov, Academic Editor Keywords: MRD, flow cytometry, immunophenotype, leukemia, myeloma, lymphoma, immunotherapy Since the last decades of the past century, the development of affordable and sensitive methods to identify...
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MRD Connect4yrKey Points • Source: Cancers • Conclusion/Relevance: “In this paper, we outlined the state-of-the-art of MFC-based MRD detection in different hematologic settings, highlighting main recommendations and new challenges for using such method Show More