Role of Radiation Based Conditioning Regimens in Patients With High-Risk AML Undergoing Allogenic Transplantation in Remission or Active Disease and Mechanisms of Post-Transplant Relapse - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35242706/
In the two decades there has been a consistent improvement in the clinical outcomes of patients diagnosed with acute leukemia undergoing allogenic stem cell transplantation. These improvements have been made...
Relevance: In this review we discuss incorporation of newer radiation techniques such as total marrow irradiation (TMI) to safely deliver targeted doses of radiation at higher doses to improve outcomes of patients with active leukemia. We also discuss the mechanisms associated with leukemia relapse and treatment options available in post...
UMAP Based Anomaly Detection for Minimal Residual Disease Quantification within Acute Myeloid Leukemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35205645/
Leukemia is the most frequent malignancy in children and adolescents, with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) as the most common subtypes. Minimal residual disease (MRD) measured...
Relevance: This work shows that despite several issues yet to overcome, the merits of automated MRD quantification can be fully exploited also in AML.
Treatment of Classic Hairy Cell Leukemia: Targeting Minimal Residual Disease beyond Cladribine - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35205704/
doi: 10.3390/cancers14040956. 1 Department of Internal Medicine V, Hematology and Oncology, Medical University of Innsbruck, A-6020 Innsbruck, Austria. 2 Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg,...
Conclusion: In the last decade, novel biologic insights such as identification of the driver mutation BRAF V600E have initiated the development and clinical investigation of new, chemotherapy-free, targeted drugs in HCL treatment, with encouraging efficacy in early clinical trials aimed at boosting eradication of MRD while optimizing drug...
Revealing the Mysteries of Acute Myeloid Leukemia: From Quantitative PCR through Next-Generation Sequencing and Systemic Metabolomic Profiling - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35159934/
The efforts made in the last decade regarding the molecular landscape of acute myeloid leukemia (AML) have created the possibility of obtaining patients' personalized treatment. Indeed, the improvement of accurate...
Conclusion: In this review, we performed a detailed overview of the most popular modern methods used in hematological laboratories, pointing out their vital importance for MRD monitoring in order to improve overall survival, early detection of possible relapses and treatment efficacy.
Phase 2 study of obinutuzumab (GA-101), ibrutinib and venetoclax (CLL2-GIVe) in patients with untreated high-risk chronic lymphocytic leukemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35108374/
Despite considerable treatment advances with targeted therapies for patients with chronic lymphocytic leukemia (CLL) deemed high-risk (del(17p) and/or TP53 mutation), outcome is still inferior compared to other CLL patients. Combining...
Conclusion: The CLL2-GIVe treatment regimen has a manageable safety profile and is a first-line treatment of good efficacy for patients with high-risk CLL.