Droplet Digital PCR (ddPCR) for MRD Quantitation Using Ig/TCR Gene Rearrangements in Acute Lymphoblastic Leukemia: A Proposed Analytic Algorithm
Source : https://www.jmdjournal.org/article/S1525-1578(22)00075-7/fulltext
In minimal residual disease (MRD), where there are exceedingly low target copy numbers, droplet digital PCR (ddPCR) can improve the quantitation. However, we currently lack the standards for ddPCR data...
Conclusion: Compared to qPCR, for Ig/TCR-based MRD quantitation, ddPCR could improve MRD sensitivity by one log10. We proposed an automatable, statistics-based algorithm that minimized inter-operator variance for ddPCR MRD.
Risk Stratification Before and During Treatment in Newly Diagnosed Multiple Myeloma: From Clinical Trials to the Real-World Setting - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35356221/
Multiple Myeloma (MM) is a hematologic malignancy characterized by a wide clinical and biological heterogeneity leading to different patient outcomes. Various prognostic tools to stratify newly diagnosed (ND)MM patients into...
Relevance: This mini review will cover currently known prognostic factors identified before and during first-line treatment, with a particular focus on their potential applications in real-world clinical practice.
In-vivo T-cell depleted reduced-intensity conditioned allogeneic haematopoietic stem-cell transplantation for patients with acute lymphoblastic leukaemia in first remission: results from the prospective, single-arm evaluation of the UKALL14 trial
Source : https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(22)00036-9/fulltext
FMA reduced-intensity conditioned allogeneic HSCT in older patients with acute lymphoblastic leukaemia in first complete remission provided good disease control with moderate GVHD, resulting in better-than-expected event-free survival and overall...
Interpretation: FMA reduced-intensity conditioned allogeneic HSCT in older patients with acute lymphoblastic leukemia in first complete remission provided good disease control with moderate GVHD, resulting in better-than-expected event-free survival and overall survival in this high-risk population. Strategies to reduce infection-related TRM...
Increasing Role of Targeted Immunotherapies in the Treatment of AML - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35328721/
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The standard of care in medically and physically fit patients is intensive induction therapy. The majority of these...
Conclusion/Relevance: In this review, established but also emerging immunotherapeutic approaches for AML patients will be discussed.
The potential of liquid biopsy in the management of cancer patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35331850/
Over the last decade, liquid biopsy has gained much attention as a powerful tool in personalized medicine, since it enables monitoring cancer evolution and follow-up of cancer patients in real...
Conclusion/Relevance: The recent findings in the field of liquid biopsy and the benefits and main clinical applications of CTC and ctDNA analysis in solid tumors are summarized in this review.