Real-world use of blinatumomab in adult patients with B-cell acute lymphoblastic leukemia in clinical practice: results from the NEUF study - Blood Cancer Journal
Source : https://www.nature.com/articles/s41408-022-00766-7
This retrospective observational study (NEUF) included adult patients with B-cell acute lymphoblastic leukemia (B-cell ALL) who had received blinatumomab for the treatment of minimal residual disease-positive (MRD+) or relapsed/refractory (R/R)...
Conclusions: These results from the largest European real-word cohort of adults with B-cell ALL are consistent with data from clinical and real-world studies, confirming the effectiveness of blinatumomab in both the MRD and R/R settings.
phase 1/2 study of lenalidomide and obinutuzumab with CHOP for newly diagnosed DLBCL
Research Article | Hua-Jay Jeffery Cherng, Stefan Alig, Yasuhiro Oki, Loretta J. Nastoupil, Luis E. Fayad, Sattva S. Neelapu, Francesco Turturro, Fredrick B. Hagemeister, Alexander Craig, Charles Macaulay, Maria A....
Conclusions: Lenalidomide, obintuzumab, and CHOP chemotherapy is an efficacious and well tolerated treatment for newly diagnosed DLBCL. LO-CHOP led to high molecular response rates by circulating tumor DNA sequencing during and after treatment in this phase Ib/II study
Overexpression of BCL2, BCL6, VEGFR1 and TWIST1 in CTCs | OTT
Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of lymphoma in Mexico (approximately between 30% and 50% of the total new cases). DLBCL represents a heterogeneous group of...
Conclusions: This study showed that in liquid biopsies analyzed, the presence of CTCs can be confirmed through molecular biomarkers, and it has an impact on OS and EFs, making this detection useful in the follow-up and prognosis of patients with DLBCL.
Platelet caspase-1 and Bruton tyrosine kinase activation in patients with COVID-19 is associated with disease severity and reversed in vitro by ibrutinib - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36514346/
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Conclusions: Our results show that caspase-1 and BTK activation are related to disease severity and suggest the therapeutic hope raised by ibrutinib in the treatment of COVID-19 by reducing the procoagulant state of the patients
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"Friends and foes" of multiple myeloma measurable/minimal residual disease evaluation by next generation flow
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.1057713/full
Next Generation Flow (NGF) represents a gold standard for the evaluation of Minimal Residual Disease (MRD) in Multiple Myeloma (MM) patients at any stage of treatment. Although the assessment of...
Conclusions: The optimization of the quality of BM samples and the analytic expertise that permits to discriminate properly the rare pathologic clones, are the keys for obtaining results with a high clinical value that could be of great impact and relevance in the future.