Insulin analogs in the treatment of type II diabetes and future perspectives
Source : https://www.sciencedirect.com/science/article/abs/pii/S0011502922001018?via=ihub
Available online 27 April 2022, 101417 The discovery of insulin by Banting and Best marked 100 years in 2021, and it was a life-saving treatment modality for type II diabetes...
Conclusion/Relevance: This review explores the currently available insulin analogs, their clinical implications, pharmacokinetics (PK), pharmacodynamics (PD), safety profile, and cost-effectiveness. We also discuss the future developments in the management of T2DM, especially the scientific advancements surrounding the novel insulin...
Financial evaluation of value-creating biosimilar development candidates: a business case study of low-, medium- and high-sales biosimilars - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35488437/
Background: Selection of a biosimilar development candidate requires detailed and careful analysis to ensure value creation. Research design and methods: We applied the net present value (NPV) model for financial...
Conclusion: Biosimilar development candidate selection requires a thorough financial evaluation considering product-, company- and market-specific aspects.
The second decade of anti-TNF-a therapy in clinical practice: new lessons and future directions in the COVID-19 era - Rheumatology International
Source : https://link.springer.com/article/10.1007/s00296-022-05136-x
Since the late 1990s, tumor necrosis factor alpha (TNF-α) inhibitors (anti-TNFs) have revolutionized the therapy of immune-mediated inflammatory diseases (IMIDs) affecting the gut, joints, skin and eyes. Although the therapeutic...
Relevance: The introduction of biosimilars had major socioeconomic impact, giving the opportunity to increased use of anti-TNF-α therapies worldwide. Finally, we briefly describe the future of anti-TNF-α therapy, including the next generation of anti-TNF-α drugs, as well as the possible combination of anti-TNFs with other biologic and...
Regulatory aspects of biological medicines in Bosnia and Herzegovina
Source : https://bjbms.org/ojs/index.php/bjbms/article/view/6910
Biljana Tubić Department of Pharmacy, Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina; Agency for Medicines and Medical Devices of Bosnia and Herzegovina, Banja Luka, Bosnia...
Relevance: These recommendations include, but are not limited to, strengthening the national regulatory framework for biologics, capacity building, increasing awareness among healthcare providers for reporting adverse drug events and active pharmacovigilance, and better definitions of interchangeability. Finally, awareness among healthcare...
A randomized pharmacokinetic and pharmacodynamic trial of two regular human insulins demonstrates bioequivalence in type 1 diabetes and availability of biosimilar insulin may improve access to this medication - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35441466/
Test product Regular Human Insulin (Bioton S.A.-Poland) and comparator Humulin® R (Eli Lilly-USA) are bioequivalent in patients with T1DM. Wider entry of more-affordable. affordable, biosimilar regular insulins on the pharmaceutical...
Conclusions: Test product Regular Human Insulin (Bioton S.A.-Poland) and comparator Humulin® R (Eli Lilly-USA) are bioequivalent in patients with T1DM. Wider entry of more-affordable. affordable, biosimilar regular insulins on the pharmaceutical market may substantially improve access to insulin for many socioeconomically disadvantaged...