Biosimilar medicines uptake: The role of the clinical pharmacist
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031038/
The introduction of biological medicines has revolutionized the management of chronic diseases. Due to the high cost of biological medicine coupled with the fact that patents of many of these...
Conclusion/Relevance: This paper aims to highlight the role of the clinical pharmacist (CP) in the utilization of biosimilars and the need for a pharmacy specialty regarding biosimilars. Of all the healthcare providers, CP has the most holistic view of the biosimilar products' clinical profile, and logistical and supply chain considerations....
Insulin analogs in the treatment of type II diabetes and future perspectives
Source : https://www.sciencedirect.com/science/article/abs/pii/S0011502922001018?via=ihub
Available online 27 April 2022, 101417 The discovery of insulin by Banting and Best marked 100 years in 2021, and it was a life-saving treatment modality for type II diabetes...
Conclusion/Relevance: This review explores the currently available insulin analogs, their clinical implications, pharmacokinetics (PK), pharmacodynamics (PD), safety profile, and cost-effectiveness. We also discuss the future developments in the management of T2DM, especially the scientific advancements surrounding the novel insulin...
Financial evaluation of value-creating biosimilar development candidates: a business case study of low-, medium- and high-sales biosimilars - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35488437/
Background: Selection of a biosimilar development candidate requires detailed and careful analysis to ensure value creation. Research design and methods: We applied the net present value (NPV) model for financial...
Conclusion: Biosimilar development candidate selection requires a thorough financial evaluation considering product-, company- and market-specific aspects.
The second decade of anti-TNF-a therapy in clinical practice: new lessons and future directions in the COVID-19 era - Rheumatology International
Source : https://link.springer.com/article/10.1007/s00296-022-05136-x
Since the late 1990s, tumor necrosis factor alpha (TNF-α) inhibitors (anti-TNFs) have revolutionized the therapy of immune-mediated inflammatory diseases (IMIDs) affecting the gut, joints, skin and eyes. Although the therapeutic...
Relevance: The introduction of biosimilars had major socioeconomic impact, giving the opportunity to increased use of anti-TNF-α therapies worldwide. Finally, we briefly describe the future of anti-TNF-α therapy, including the next generation of anti-TNF-α drugs, as well as the possible combination of anti-TNFs with other biologic and...
Regulatory aspects of biological medicines in Bosnia and Herzegovina
Source : https://bjbms.org/ojs/index.php/bjbms/article/view/6910
Biljana Tubić Department of Pharmacy, Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina; Agency for Medicines and Medical Devices of Bosnia and Herzegovina, Banja Luka, Bosnia...
Relevance: These recommendations include, but are not limited to, strengthening the national regulatory framework for biologics, capacity building, increasing awareness among healthcare providers for reporting adverse drug events and active pharmacovigilance, and better definitions of interchangeability. Finally, awareness among healthcare...