Prognostic Value of Hematogones in Patients With Hematopoietic Disorders After Allogeneic Hematopoietic Stem Cell Transplantation: a Systematic Review and Meta-Analysis
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580303/
This systematic review and meta-analysis aimed to determine whether hematogones in patients with hematopoietic disorders after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with clinical outcomes.
Evidence regarding the association between hematogones, relapse, and infections is uncertain. Hematogones may be a prognostic factor for long-term prognosis and acute adverse events in patients with hematopoietic disorders after allo-HSCT.
The Association of Intestinal Microbiota Diversity and Outcomes of Allogeneic Hematopoietic Cell Transplantation: a Systematic Review and Meta-Analysis
Source : https://link.springer.com/article/10.1007/s00277-023-05460-7
Growing evidence suggests that highly intestinal microbiota diversity modulates host inflammation and promotes immune tolerance. Several studies have reported that patients undergoing allo-HSCT have experienced microbiota disruption that is characterized...
This meta-analysis highlights the protective role of higher intestinal microbiota diversity on outcomes after allo-HSCT during both pre-transplant and post-transplant periods. Some specific microbiota can be useful in the identification of patients at risk of mortality, offering new tools for individualized pre-emptive or therapeutic...
Novel Therapies for Graft-Versus-Host Disease With a Focus on Cell Therapies
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241068/full
Graft versus host disease (GVHD) can occur at any period post allogeneic hematopoietic stem cell transplantation as a common clinical complication contributing to significant morbidity and mortality. Acute GVHD develops...
DSC-based treatments will reach full-scale production and manufacturing phases over the next decade. The present indications for most cell therapies include diseases with few to no current treatments, high mortality rates, and substantial threats to the quality of life. It will also be interesting to see the use for cell therapy treatments...
Severity of Chronic Graft-versus-Host Disease and Late Effects Following Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancy
Source : https://pubmed.ncbi.nlm.nih.gov/37844687/
Chronic GVHD appeared closely associated with both SN and NM-LE in adult survivors of HCT for hematologic malignancy. Patients identified as having more severe involvement and both mucocutaneous and visceral...
Chronic GVHD appeared closely associated with both SN and NM-LE in adult survivors of HCT for hematologic malignancy. Patients identified as having more severe involvement and both mucocutaneous and visceral organ involvement may warrant enhanced monitoring and screening for SNs and NM-LEs.
Incidence and Risk Factors of Graft-Versus-Host Disease After Liver Transplantation: a National Study 2010–2020
haring. This is the first national analysis of the incidence and risk factors of GVHD after LT. Methods: This retrospective cohort study used the National Readmission Database to calculate the...
Our study found that the incidence rate of GVHD within 1 year of LT in the United States was 1.0% and remained stable from 2010 to 2020. The predictors associated with GVHD include alcohol-associated liver disease and COVID-19.