Understanding the Needs and Lived Experiences of Patients With Graft-Versus-Host Disease: Real-World European Public Social Media Listening Study
Source : https://cancer.jmir.org/2023/1/e42905
Background: Graft-versus-host disease (GVHD) is the major cause of short- and long-term morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Treatment options beyond corticosteroid therapy remain limited, and prolonged...
SM listening is a useful tool to identify medical needs. Treatment of GVHD, including treatment-related side effects, as well as its emotional and physical impact on QoL, are the major topics that GVHD stakeholders mention on SM. We encourage a structured discussion of these topics in interactions between health care providers and patients...
Novel Approaches to Treatment of Acute Myeloid Leukemia Relapse Post Allogeneic Stem Cell Transplantation
Source : https://www.mdpi.com/1422-0067/24/19/15019
The management of patients with acute myeloid leukemia (AML) relapsed post allogeneic hematopoietic stem cell transplantation (HSCT) remains a clinical challenge. Intensive treatment approaches are limited by severe toxicities in...
Despite discordant results, addition of donor lymphocytes infusions generally granted improved outcomes with manageable GvHD incidence. Recent introduction of novel targeted drugs in AML gives the opportunity to add a third element to salvage regimens.
Prognostic Value of Hematogones in Patients With Hematopoietic Disorders After Allogeneic Hematopoietic Stem Cell Transplantation: a Systematic Review and Meta-Analysis
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580303/
This systematic review and meta-analysis aimed to determine whether hematogones in patients with hematopoietic disorders after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with clinical outcomes.
Evidence regarding the association between hematogones, relapse, and infections is uncertain. Hematogones may be a prognostic factor for long-term prognosis and acute adverse events in patients with hematopoietic disorders after allo-HSCT.
The Association of Intestinal Microbiota Diversity and Outcomes of Allogeneic Hematopoietic Cell Transplantation: a Systematic Review and Meta-Analysis
Source : https://link.springer.com/article/10.1007/s00277-023-05460-7
Growing evidence suggests that highly intestinal microbiota diversity modulates host inflammation and promotes immune tolerance. Several studies have reported that patients undergoing allo-HSCT have experienced microbiota disruption that is characterized...
This meta-analysis highlights the protective role of higher intestinal microbiota diversity on outcomes after allo-HSCT during both pre-transplant and post-transplant periods. Some specific microbiota can be useful in the identification of patients at risk of mortality, offering new tools for individualized pre-emptive or therapeutic...
Novel Therapies for Graft-Versus-Host Disease With a Focus on Cell Therapies
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241068/full
Graft versus host disease (GVHD) can occur at any period post allogeneic hematopoietic stem cell transplantation as a common clinical complication contributing to significant morbidity and mortality. Acute GVHD develops...
DSC-based treatments will reach full-scale production and manufacturing phases over the next decade. The present indications for most cell therapies include diseases with few to no current treatments, high mortality rates, and substantial threats to the quality of life. It will also be interesting to see the use for cell therapy treatments...