Elevation of Tacrolimus Concentration After Administration of Methotrexate for Treatment of Graft-Versus-Host Disease in Pediatric Patients Received Allogeneic Hematopoietic Stem Cell Transplantation
Source : https://jphcs.biomedcentral.com/articles/10.1186/s40780-023-00306-w
Methotrexate (MTX) is used to treat graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, a case was encountered in which the blood concentration of tacrolimus (TCR) at...
The C/D value significantly increased after therapeutic IV-methotrexate administration, indicating a reduction in the apparent clearance of TCR. Along with the increase in C/D, significant increases were observed in aspartate transaminase and alanine aminotransferase levels, indicating that liver injury after therapeutic intravenous...
Incidence, Risk Factors, Characteristics, and Outcome of Chronic Graft Versus Host Disease in Children Undergoing Haploidentical Peripheral Blood Stem Cell Transplant With Post-Transplant Cyclophosphamide
Source : https://pubmed.ncbi.nlm.nih.gov/37983773/
Incidence of cGVHD was high in children undergoing haploidentical PBSCT with PTCy. Other than PBSC graft source; donor age and previous aGVHD were the risks factors for development of cGVHD.
Compared with patients without cGVHD, patients with cGVHD demonstrated a lower relapse, higher EFS, and higher OS.
Chronic Graft-Versus-Host Disease Is Characterized by High Levels and Distinctive Tissue-of-Origin Patterns of Cell-Free DNA
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651673/
Chronic graft-versus-host disease (cGvHD) is a devastating complication of hematopoietic stem cell transplantation (HSCT). Effective early detection may improve the outcome of cGvHD.
Chronic graft-versus-host disease (cGvHD) had unique cfDNA signatures, and CfDNA patterns are potentially useful biomarkers for cGvHD.
BMQI is a relevant, simple, timely, and inexpensive quality indicator in the context of G-CSF-primed BM. Poorer quality of marrow collection may contribute to an increased risk of aGVHD.
Unconventional T cells with restricted TCR repertoire have shown favorable antitumor potency with near zero incidence of GvHD.