Longitudinal Dynamics of Gut Microbiota in the Pathogenesis of Acute Graft-Versus-Host Disease
Source : https://pubmed.ncbi.nlm.nih.gov/38053512/
Dynamic changes in gut microbiota composition and related cytokines were found to be related to aGvHD, including pathogenic or protective changes. These findings suggested that manipulation of gut microbiota at...
A prospective cohort study demonstrated the longitudinal dynamics of gut microbiota during the process of allo-HSCT and analyzed the GvHD-related microbiota and cytokines at preconditioning, day of graft infusion, period of engraftment, and 30 days after transplantation.
Chronic Graft Versus Host Disease Detected by Tissue-Specific Cell-Free DNA Methylation Biomarkers
Source : https://pubmed.ncbi.nlm.nih.gov/37971879/
This work was supported by grants from the Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine, The Israel Science Foundation, the Waldholtz / Pakula family, the Robert...
An integrative model taking into account total cfDNA concentration, monocyte/macrophage cfDNA levels and alanine transaminase was able to correctly identify GVHD with a specificity of 86% and precision of 89%.
Elevation of Tacrolimus Concentration After Administration of Methotrexate for Treatment of Graft-Versus-Host Disease in Pediatric Patients Received Allogeneic Hematopoietic Stem Cell Transplantation
Source : https://jphcs.biomedcentral.com/articles/10.1186/s40780-023-00306-w
Methotrexate (MTX) is used to treat graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, a case was encountered in which the blood concentration of tacrolimus (TCR) at...
The C/D value significantly increased after therapeutic IV-methotrexate administration, indicating a reduction in the apparent clearance of TCR. Along with the increase in C/D, significant increases were observed in aspartate transaminase and alanine aminotransferase levels, indicating that liver injury after therapeutic intravenous...
Incidence, Risk Factors, Characteristics, and Outcome of Chronic Graft Versus Host Disease in Children Undergoing Haploidentical Peripheral Blood Stem Cell Transplant With Post-Transplant Cyclophosphamide
Source : https://pubmed.ncbi.nlm.nih.gov/37983773/
Incidence of cGVHD was high in children undergoing haploidentical PBSCT with PTCy. Other than PBSC graft source; donor age and previous aGVHD were the risks factors for development of cGVHD.
Compared with patients without cGVHD, patients with cGVHD demonstrated a lower relapse, higher EFS, and higher OS.
Chronic Graft-Versus-Host Disease Is Characterized by High Levels and Distinctive Tissue-of-Origin Patterns of Cell-Free DNA
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651673/
Chronic graft-versus-host disease (cGvHD) is a devastating complication of hematopoietic stem cell transplantation (HSCT). Effective early detection may improve the outcome of cGvHD.
Chronic graft-versus-host disease (cGvHD) had unique cfDNA signatures, and CfDNA patterns are potentially useful biomarkers for cGvHD.