Adherence to Immunosuppressants Among Adult Patients After Allogeneic Hematopoietic Stem-Cell Transplantation (Allo-HSCT): a Cross-Sectional Study
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700097/
Background: The level of adherence to drug therapy after allogeneic hematopoietic stem-cell transplantation (Allo-HSCT) can affect the patient's outcome, and poor adherence is one of the factors in first-year mortality...
Cyclosporine plays the most important role after the allo-HSCT period since it prevents GVHD, and this study indicated that blood level directly correlates with patient adherence. With 1 score increase, the cyclosporine level also rises about 35 ng/mL on average.
A Personalized, Organ-Based Approach to the Treatment of Chronic Steroid-Refractory Graft-Versus-Host Disease
Source : https://www.sciencedirect.com/science/article/abs/pii/S0268960X23001030?via=ihub
Chronic graft-versus-host-disease (cGvHD) remains the leading cause of morbidity among transplant recipients. The efficacy of second-line treatments v...
A personalized organ-based approach to the selection of therapeutic agents in cGvHD can result in a more favorable patient outcome and achieve a better organ-specific response.
Non-GVHD Enterocolitis Following Cord Blood Transplant Is Real, With Poorly Understood Pathophysiology, and Requires Distinct Management From GVHD, With Eventual Resolution Without Immune Suppression
Source : https://www.sciencedirect.com/science/article/abs/pii/S2666636723017128?via=ihub
Enterocolitis is common after cord blood transplant (CBT) and a specific, non-GVHD entity with specific histopathologic features ("cord colitis") ha...
Overall survival was superior in the non-GVHD enterocolitis cohort compared with the GVHD group, and the duration of immune suppression was shorter for non-GVHD enterocolitis patients, reflecting the need for different management approaches.
Longitudinal Dynamics of Gut Microbiota in the Pathogenesis of Acute Graft-Versus-Host Disease
Source : https://pubmed.ncbi.nlm.nih.gov/38053512/
Dynamic changes in gut microbiota composition and related cytokines were found to be related to aGvHD, including pathogenic or protective changes. These findings suggested that manipulation of gut microbiota at...
A prospective cohort study demonstrated the longitudinal dynamics of gut microbiota during the process of allo-HSCT and analyzed the GvHD-related microbiota and cytokines at preconditioning, day of graft infusion, period of engraftment, and 30 days after transplantation.
Chronic Graft Versus Host Disease Detected by Tissue-Specific Cell-Free DNA Methylation Biomarkers
Source : https://pubmed.ncbi.nlm.nih.gov/37971879/
This work was supported by grants from the Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine, The Israel Science Foundation, the Waldholtz / Pakula family, the Robert...
An integrative model taking into account total cfDNA concentration, monocyte/macrophage cfDNA levels and alanine transaminase was able to correctly identify GVHD with a specificity of 86% and precision of 89%.