Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2 - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34326465/

Mutations in the Janus Kinase 2 (JAK2) gene resulting in constitutive kinase activation represent the most common genetic event in myeloproliferative neoplasms (MPN), a group of diseases involving overproduction of...

Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34324169/

doi: 10.1007/s11523-021-00830-5. Online ahead of print. 1 Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, TN, USA. 2 Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA....

Deletion of AMPK minimizes graft-versus-host disease through an early impact on effector donor T cells - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34291733/

Allogeneic hematopoietic stem cell transplantation is a viable treatment for multiple hematologic diseases, but its application is often limited by graft-versus-host disease (GVHD), where donor T cells attack host tissues...

HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34292325/

1 Department of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA. 2 Center for International Blood and Marrow Transplant Research (CIBMTR), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI. 3 Division...

Graft Versus Host Disease After Intestinal Transplantation: A Single-center Experience - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34291153/

doi: 10.1097/TXD.0000000000001187. 1 MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC. 2 Georgetown University School of Medicine, Washington, DC. 3 Histocompatibility Laboratory, MedStar Georgetown University Hospital, Washington, DC....