Maintenance therapy after allogeneic hematopoietic transplant for acute myeloid leukemia: a systematic review and meta-analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34325602/

doi: 10.1080/0284186X.2021.1955969. Online ahead of print. 1 Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel. 2 Sackler School of Medicine, Tel Aviv University, Tel...

Lower response to BNT162b2 vaccine in patients with myelofibrosis compared to polycythemia vera and essential thrombocythemia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34325728/

In a population of 42 Philadelphia negative myeloproliferative neoplasm patients, all on systemic active treatment, the likelihood of responding to anti-SARS-CoV-2 BNT162b2 vaccine at 2 weeks after the second dose...

Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2 - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34326465/

Mutations in the Janus Kinase 2 (JAK2) gene resulting in constitutive kinase activation represent the most common genetic event in myeloproliferative neoplasms (MPN), a group of diseases involving overproduction of...

Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34324169/

doi: 10.1007/s11523-021-00830-5. Online ahead of print. 1 Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, TN, USA. 2 Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA....

Deletion of AMPK minimizes graft-versus-host disease through an early impact on effector donor T cells - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34291733/

Allogeneic hematopoietic stem cell transplantation is a viable treatment for multiple hematologic diseases, but its application is often limited by graft-versus-host disease (GVHD), where donor T cells attack host tissues...