The role of biomarkers in risk stratification, treatment and outcome in acute GVHD - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34475350/

Biomarkers are now being incorporated into the clinical trial design for both high and low-risk GVHD. These findings will likely impact how clinical care is delivered in the future as...

Impact of HLA disparity on the risk of overall mortality in patients with grade II-IV acute GVHD on behalf of the HLA Working Group of Japan Society for Hematopoietic Cell Transplantation - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34480119/

Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Stem cell source or HLA disparity may exert a significant impact on...

An investigation of the diagnostic, predictive, and prognostic impacts of three colonic biopsy grading systems for acute graft versus host disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34437603/

1 Institute of Pathology, University Medical Center Mainz, Mainz, Germany. 2 Institute of Pathology, University Hospital Regensburg, Regensburg, Germany. 3 3rd Medical Department, Hematology, Oncology and Pneumology, University Medical Center...

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34436524/

Immunopathology and intestinal stem cell (ISC) loss in the gastrointestinal (GI) tract is the prima facie manifestation of graft-versus-host disease (GVHD) and is responsible for significant mortality after allogeneic bone...

Donor-derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34410039/

doi: 10.1002/iid3.503. Online ahead of print. 1 Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie, Japan. 2 Department of Pathology and Matrix Biology, Mie University Graduate School...