Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34630383/
Programmed cell death protein-1 (PD-1) is an inhibitory co-receptor required for regulating immune responsiveness and maintaining immune homeostasis. As PD-1 can be released as bioactive soluble molecule, we investigated the...
Differential effects of donor lymphocyte infusion upon treatment response and GVHD according to relapse level and donor sources in patients with myelodysplastic syndrome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34589195/
Despite being limited by small number of cases and its retrospective nature, this study again demonstrated the therapeutic effects of DLI in relapsed MDS, and that earlier detection and intervention...
Cardiac Toxicity after Matched Allogeneic Hematopoietic Cell Transplantation in the Post-Transplant Cyclophosphamide Era - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34592759/
2021 Sep 30;bloodadvances.2021004846. doi: 10.1182/bloodadvances.2021004846. Online ahead of print. 1 University of Texas MD Anderson Cancer Center, Houston, Texas, United States. 2 MD Anderson Cancer Center, Houston, Texas, United States....
Mouse Models of Antigen Presentation in Hematopoietic Stem Cell Transplantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34594330/
Allogeneic stem cell transplantation (alloSCT) is a curative therapy for hematopoietic malignancies. The therapeutic effect relies on donor T cells and NK cells to recognize and eliminate malignant cells, known...
Vitamin D deficiency after allogeneic hematopoietic cell transplantation promotes T-cell activation and is inversely associated with an EZH2-ID3 signature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34597852/
Vitamin D promotes a shift from a pro-inflammatory to a more tolerogenic immune state in allogeneic hematopoietic cell transplantation (HCT) recipients. The dominant mechanism responsible for this shift has not...