IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34436524/

Immunopathology and intestinal stem cell (ISC) loss in the gastrointestinal (GI) tract is the prima facie manifestation of graft-versus-host disease (GVHD) and is responsible for significant mortality after allogeneic bone...

Donor-derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34410039/

doi: 10.1002/iid3.503. Online ahead of print. 1 Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie, Japan. 2 Department of Pathology and Matrix Biology, Mie University Graduate School...

Co-transplantation of mesenchymal stromal cell and haploidentical hematopoietic stem cell with TCR αβ depletion in children with primary immunodeficiency syndromes - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34409718/

We conclude that use of TCR αβ depleted haploidentical transplantation with MSCs may ensure a rapid engraftment rate, low incidence of significant acute and chronic GVHD, and acceptable post-transplantation morbidity,...

Chronic liver graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients during tapering or after stopping calcineurin inhibitors - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34378178/

Chronic graft-versus-host disease (cGVHD) of the liver is often observed in allogeneic hematopoietic stem cell transplantation (allo-HSCT) during tapering or after stopping calcineurin inhibitors (CI). We conducted a retrospective analysis...

Influence of Killer Immunoglobulin-like Receptors and Somatic Mutations on Transplant Outcomes in Acute Myeloid Leukemia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34380091/

Enhanced NK cell alloreactivity from more KIR activating signals (donor B haplotype) and less inhibitory signals (recipient missing KIR ligand or C1 or C2 homozygosity) may help mitigate the adverse...