Differential effects of donor lymphocyte infusion upon treatment response and GVHD according to relapse level and donor sources in patients with myelodysplastic syndrome - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34589195/

Despite being limited by small number of cases and its retrospective nature, this study again demonstrated the therapeutic effects of DLI in relapsed MDS, and that earlier detection and intervention...

Cardiac Toxicity after Matched Allogeneic Hematopoietic Cell Transplantation in the Post-Transplant Cyclophosphamide Era - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34592759/

2021 Sep 30;bloodadvances.2021004846. doi: 10.1182/bloodadvances.2021004846. Online ahead of print. 1 University of Texas MD Anderson Cancer Center, Houston, Texas, United States. 2 MD Anderson Cancer Center, Houston, Texas, United States....

Mouse Models of Antigen Presentation in Hematopoietic Stem Cell Transplantation - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34594330/

Allogeneic stem cell transplantation (alloSCT) is a curative therapy for hematopoietic malignancies. The therapeutic effect relies on donor T cells and NK cells to recognize and eliminate malignant cells, known...

Vitamin D deficiency after allogeneic hematopoietic cell transplantation promotes T-cell activation and is inversely associated with an EZH2-ID3 signature - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34597852/

Vitamin D promotes a shift from a pro-inflammatory to a more tolerogenic immune state in allogeneic hematopoietic cell transplantation (HCT) recipients. The dominant mechanism responsible for this shift has not...

Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34556806/

In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation (allo-BMT) by using the proteasome inhibitor ixazomib (IXZ) at the late...