Impact of HLA disparity on the risk of overall mortality in patients with grade II-IV acute GVHD on behalf of the HLA Working Group of Japan Society for Hematopoietic Cell Transplantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34480119/
Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Stem cell source or HLA disparity may exert a significant impact on...
An investigation of the diagnostic, predictive, and prognostic impacts of three colonic biopsy grading systems for acute graft versus host disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34437603/
1 Institute of Pathology, University Medical Center Mainz, Mainz, Germany. 2 Institute of Pathology, University Hospital Regensburg, Regensburg, Germany. 3 3rd Medical Department, Hematology, Oncology and Pneumology, University Medical Center...
IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34436524/
Immunopathology and intestinal stem cell (ISC) loss in the gastrointestinal (GI) tract is the prima facie manifestation of graft-versus-host disease (GVHD) and is responsible for significant mortality after allogeneic bone...
Donor-derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34410039/
doi: 10.1002/iid3.503. Online ahead of print. 1 Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie, Japan. 2 Department of Pathology and Matrix Biology, Mie University Graduate School...
Co-transplantation of mesenchymal stromal cell and haploidentical hematopoietic stem cell with TCR αβ depletion in children with primary immunodeficiency syndromes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34409718/
We conclude that use of TCR αβ depleted haploidentical transplantation with MSCs may ensure a rapid engraftment rate, low incidence of significant acute and chronic GVHD, and acceptable post-transplantation morbidity,...