Crosstalk Between Intestinal Microbiota Derived Metabolites and Tissues in Allogeneic Hematopoietic Cell Transplantation - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34512627/

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an evidence based- cellular immunotherapy for hematological malignancies. Immune reactions not only promote graft-versus-tumor effects that kill hematological malignant cells but also graft-versus-host...

Novel Insights Into the Mechanism of GVHD-Induced Tissue Damage - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34512636/

Prophylaxis for and treatment of graft-versus-host disease (GVHD) are essential for successful allogeneic hematopoietic stem cell transplantation (allo-SCT) and mainly consist of immunosuppressants such as calcineurin inhibitors. However, profound immunosuppression...

Graft-versus-host disease prophylaxis using low-dose antithymocyte globulin in peripheral blood stem cell transplantation - A matched-pair analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34500126/

Antithymocyte globulin (ATG) decreases chronic graft-versus-host disease (cGVHD) in peripheral blood stem cell transplantation (PBSCT); however, the optimal ATG dose has not been elucidated. We conducted a matched-pair analysis to...

Ruxolitinib exposure in patients with acute and chronic graft versus host disease in routine clinical practice-a prospective single-center trial - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34505930/

doi: 10.1007/s00280-021-04351-w. Online ahead of print. 1 Department of Internal Medicine II, University Hospital Würzburg, Oberdürrbacher Strasse 6, 97080, Würzburg, Germany. [email protected]. 2 Department of Internal Medicine II, University Hospital...

The role of biomarkers in risk stratification, treatment and outcome in acute GVHD - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34475350/

Biomarkers are now being incorporated into the clinical trial design for both high and low-risk GVHD. These findings will likely impact how clinical care is delivered in the future as...