Risk Factors and Clinical Characteristics of Acute and Chronic Cutaneous Graft-Versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation
Source : https://pubmed.ncbi.nlm.nih.gov/37830789/
Acute and chronic cutaneous graft-versus-host disease (GVHD) are common complications following hematopoietic stem cell transplantation (HSCT) in pediatric patients. In this retrospective study, we explored the risk factors and clinical...
Our study highlights the importance of identifying and monitoring these high-risk patients to improve the clinical management and outcomes of cutaneous GVHD in pediatric HSCT recipients.
Adolescent and Young Adult Patients with Vaginal Graft-Versus-Host Disease and Hematocolpos Managed With Vaginal Stents: a Case Series
Source : https://pubmed.ncbi.nlm.nih.gov/37797789/
Vaginal stenosis secondary to vaginal GVHD should be considered in patients with a history of allogeneic HSCT presenting with amenorrhea, especially those with a diagnosis of primary ovarian insufficiency. The...
Vaginal stenosis secondary to vaginal GVHD should be considered in patients with a history of allogeneic HSCT presenting with amenorrhea, especially those with a diagnosis of primary ovarian insufficiency. The use of vaginal stents, along with postoperative medical and dilator management as appropriate, may prevent re-stenosis, although more...
Propensity Score Matching Analysis Comparing the Efficacy and Steroid Tapering Benefit of Extracorporeal Photopheresis to Best Available Therapy in Third-Line or Beyond Treatment for Chronic GvHD
Source : https://www.sciencedirect.com/science/article/abs/pii/S2666636723015750?via=ihub
Graft-versus host disease (GvHD) is one of the major limitations to allogeneic hematopoietic stem cell transplantation (HCT). While corticosteroids ...
The current study demonstrates superior FFS, OS and steroid tapering efficacy for ECP vs BAT as third-line therapy or beyond in cGvHD patients.
Targeting Hedgehog Signaling with Glasdegib in Patients with Refractory Sclerotic Chronic GVHD: A Report of Two Phase I/II Trials
AbstractPurpose:. Sclerotic chronic GVHD (scGVHD) is characterized by progressive skin fibrosis and frequent refractoriness to available therapies. Aberrant activation of Hedgehog signaling in dermal fibroblasts has been implicated in scGVHD....
Glasdegib demonstrated promising responses in patients with refractory scGVHD, but tolerability was limited by muscle cramping.
Single Centre Retrospective Analysis of Extracorporeal Photopheresis (ECP) Therapy in Patients Heavily Pre-Treated for Chronic Graft-Versus-Host Disease (cGvHD) With Steroid Failure
Source : https://www.sciencedirect.com/science/article/pii/S0145212623006525?via=ihub
Extracorporeal photopheresis (ECP) is recommended as a second- or later-line therapy for chronic GvHD (cGvHD). Benefits include reasonable response wi...
ECP is an effective treatment option for heavily pre-treated cGvHD patients.