Mismatched Unrelated vs Matched Related Donor Transplant With Posttransplant Cyclophosphamide Among Patients With Blood Cancers. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42475099
Study explores MMUD vs MRD transplants for blood cancers, noting reduced relapse in high or very high DRI cases but increased chronic GVHD.
MMUD transplants showed reduced relapse in patients with high or very high DRI blood cancers but increased chronic GVHD compared to MRD.
Graft-Versus-Host Disease After Liver Transplantation: Diagnostic and Therapeutic Challenges. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42368228
Explore GVHD post-liver transplantation: a 55-year-old's case with fever, pancytopenia, rash. Diagnosis confirmed by biopsy, treated with methylprednisolone, ruxolitinib.
A 55-year-old man developed GVHD post-liver transplantation, presenting with fever, pancytopenia, and rash. Diagnosis via biopsy and chimerism testing; treated with methylprednisolone and ruxolitinib.
The role of the microbiota in hematological malignancies: A narrative review of mechanisms and therapeutic potential. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42433272
Discover how gut microbiota influences hematological malignancies and the potential of microbiome-targeted therapies like dietary modulation and fecal transplantation in treatment.
The microbiota affects hematological malignancies through immune modulation, inflammatory signaling, and microbial metabolite interactions. Dysbiosis and treatments like chemotherapy can exacerbate these conditions.
Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42380095
Explore cancer cell therapies like CAR-T, TCR-T, and CAR-NK, focusing on allogeneic approaches and challenges in treating solid tumors.
Current cell therapies, including CAR-T, TCR-T, TILs, CAR-NK, and CAR-M, show promise, particularly in transitioning to allogeneic platforms, despite challenges like tumor heterogeneity.
The impact of T cell exhaustion in hematopoietic stem cell transplantation. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42366382
Explore how T cell exhaustion influences HSCT outcomes, affecting graft-versus-leukemia efficacy and anti-virus response, with a need for deeper mechanistic insights.
T cell exhaustion affects HSCT outcomes due to reduced graft-versus-leukemia effects and anti-virus capacity. A deeper mechanistic understanding is still needed. Disease Condition: Hematological malignancies. Specialty Focus: Oncology.