Autophagy Prevents Graft Failure During Murine Graft Versus Host Disease
Source : https://pubmed.ncbi.nlm.nih.gov/38295282/
Autophagy is an intracellular survival process that has established roles in the long-term survival and function of hematopoietic stem cells (HSC). We investigated the contribution of autophagy to HSC fitness...
Tumor necrosis factor and interleukin 1 beta, major components of graft-vs-host disease cytokine storm, synergistically promote autophagy in hematopoietic stem cells and their more mature hematopoietic progenitor cells.
Late Transplant-Associated Thrombotic Microangiopathy Verified in Bone Marrow Biopsy Specimens Is Associated With Chronic GVHD and Viral Infections
Source : https://pubmed.ncbi.nlm.nih.gov/38243840/
Chronic allo-immune microangiopathy in BM associated with chronic, steroid-refractory GVHD and/or viral infections are key findings of late, high-risk TA-TMA, which deserves clinical attention.
Researchers described alterations of vascular sinusoids consisting of atypical von Willebrand Factor–positive conglomerates forming thickened von Willebrand Factor–positive plaques in the endothelial walls of the bone marrow in patients with late transplant-associated thrombotic microangiopathy.
The Effect of Oral Chronic Graft-Versus-Host Disease on Bodyweight: a Cohort Study
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796034/
This retrospective cohort study aimed to evaluate the association between body weight and oral cGVHD (chronic graft versus host disease). Patients with oral cGVHD were compared with an age and...
Patients with oral chronic GVHD had a higher risk of being underweight versus the non-GVHD and nonoral chronic GVHD groups, with oral mucositis as an independent predictor of weight loss.
Allogeneic CAR-T Cells With of HLA-A/B and TRAC Disruption Exhibit Promising Antitumor Capacity Against B Cell Malignancies
Source : https://pubmed.ncbi.nlm.nih.gov/38231412/
The nU-CAR-T19 cells showed a strong response in R/R B-ALL. nU-CAR-T19 cells have the potential to be a promising new approach for treating R/R B cell malignancies.
Robust expansion of nU-CAR-T19 cells, along with rapid eradication of CD19+ abnormal B cells, was observed in the peripheral blood and bone marrow of another 3 patients with R/R B-ALL.
Graft-Versus-Host Disease After an Outpatient Peripheral Blood Hematopoietic Cell Transplant Using Reduced-Intensity Conditioning: a Single-Center LATAM Experience
Source : https://pubmed.ncbi.nlm.nih.gov/38226642/
Acute and chronic GvHD rates were comparable between HLA-identical and haploidentical transplant groups. cGvHD severity was lower in the haploidentical group.
Acute and chronic GvHD rates were comparable between HLA-identical and haploidentical transplant groups. Chronic GvHD severity was lower in the haploidentical group.