The Use of Teduglutide in the Management of GI GVHD in Children and Young Adults: a Case Series
Source : https://www.sciencedirect.com/science/article/abs/pii/S2666636724001775?via=ihub
Loss of intestinal L cells and reduced levels of glucagon-like peptide-2 (GLP-2) have been implicated in acute graft-versus-host disease (GVHD) in mur...
Based on the results of this series, the authors suggested 4 weeks of initial treatment followed by clinical and endoscopic reassessment to determine if longer durations of ≤12 weeks are indicated.
Graft-Versus-Host Disease and Impact on Relapse in Myelofibrosis Undergoing Hematopoietic Stem Cell Transplantation
Source : https://www.nature.com/articles/s41409-024-02220-7
Allogeneic hematopoietic stem cell transplantation (alloHSCT) remains the only curative treatment for myelofibrosis (MF). Relapse occurs in 10-30% and remains a major factor for dismal outcomes. Previous work suggested that...
Development of acute grade 2 GVHD and moderate chronic GVHD was an independent factor for reduced risk for relapse, without increased risk for nonrelapse mortality after transplantation.
Successful Use of Dupilumab in Recalcitrant Pediatric Atopic Dermatitis-Like Graft-Versus-Host Disease: a Case Series
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824674/
Lina Belmesk, MD, a Afshin Hatami, MD, b Julie Powell, MD, b Victor Kokta, MD, c and Jerome Coulombe, MD b, ∗ Graft-versus-host disease (GvHD) is one of the most...
All 4 study patients achieved near complete clearance, considerable pruritus reduction, and improved quality of life after receiving dupilumab.
Autophagy Prevents Graft Failure During Murine Graft Versus Host Disease
Source : https://pubmed.ncbi.nlm.nih.gov/38295282/
Autophagy is an intracellular survival process that has established roles in the long-term survival and function of hematopoietic stem cells (HSC). We investigated the contribution of autophagy to HSC fitness...
Tumor necrosis factor and interleukin 1 beta, major components of graft-vs-host disease cytokine storm, synergistically promote autophagy in hematopoietic stem cells and their more mature hematopoietic progenitor cells.
Late Transplant-Associated Thrombotic Microangiopathy Verified in Bone Marrow Biopsy Specimens Is Associated With Chronic GVHD and Viral Infections
Source : https://pubmed.ncbi.nlm.nih.gov/38243840/
Chronic allo-immune microangiopathy in BM associated with chronic, steroid-refractory GVHD and/or viral infections are key findings of late, high-risk TA-TMA, which deserves clinical attention.
Researchers described alterations of vascular sinusoids consisting of atypical von Willebrand Factor–positive conglomerates forming thickened von Willebrand Factor–positive plaques in the endothelial walls of the bone marrow in patients with late transplant-associated thrombotic microangiopathy.