Acute Graft Versus Host Disease 1976-2020: Reduced Incidence and Predictive Factors
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847269/
We studied the incidence of acute graft versus host disease (GvHD) and its outcome in three consecutive time frames (year 2010), in 3,120 patients allografted in two transplant Centers between...
Treatment was improved as suggested by reduced TRM and improved survival in a multivariate analysis, taking into consideration the current older patient population grafted from alternative donors.
Dual T Cell Depletion for Graft Versus Host Disease Prevention in Peripheral Blood Haploidentical Hematopoietic Cell Transplantation for Adults With Hematological Malignancies
Source : https://www.nature.com/articles/s41409-024-02216-3
The ideal immunosuppressive agents to complement post-transplant cyclophosphamide (PTCy) in PBSC-based haploidentical hematopoietic cell transplantation (haplo-HCT) remain debated. This study looks at our experience with ATG-PTCy-Cyclosporine (CsA) prophylaxis in PB...
These results confirmed that using post-transplant cyclophosphamide and ATG, alongside cyclosporine is safe and effective in preventing GVHD when using peripheral blood as the stem cell source in haploidentical hematopoietic cell transplantation.
The Use of Teduglutide in the Management of GI GVHD in Children and Young Adults: a Case Series
Source : https://www.sciencedirect.com/science/article/abs/pii/S2666636724001775?via=ihub
Loss of intestinal L cells and reduced levels of glucagon-like peptide-2 (GLP-2) have been implicated in acute graft-versus-host disease (GVHD) in mur...
Based on the results of this series, the authors suggested 4 weeks of initial treatment followed by clinical and endoscopic reassessment to determine if longer durations of ≤12 weeks are indicated.
Graft-Versus-Host Disease and Impact on Relapse in Myelofibrosis Undergoing Hematopoietic Stem Cell Transplantation
Source : https://www.nature.com/articles/s41409-024-02220-7
Allogeneic hematopoietic stem cell transplantation (alloHSCT) remains the only curative treatment for myelofibrosis (MF). Relapse occurs in 10-30% and remains a major factor for dismal outcomes. Previous work suggested that...
Development of acute grade 2 GVHD and moderate chronic GVHD was an independent factor for reduced risk for relapse, without increased risk for nonrelapse mortality after transplantation.
Successful Use of Dupilumab in Recalcitrant Pediatric Atopic Dermatitis-Like Graft-Versus-Host Disease: a Case Series
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824674/
Lina Belmesk, MD, a Afshin Hatami, MD, b Julie Powell, MD, b Victor Kokta, MD, c and Jerome Coulombe, MD b, ∗ Graft-versus-host disease (GvHD) is one of the most...
All 4 study patients achieved near complete clearance, considerable pruritus reduction, and improved quality of life after receiving dupilumab.