In the treatment of Human cancer, KRAS remains an untouchable target of choice
The KRAS gene (homologous to the viral oncogene of Kirsten rat sarcoma 2) is a proto-oncogene that codes for a small GTPase transducing protein called KRAS belonging to the RAS...
Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow
Source : https://www.biorxiv.org/content/10.1101/2021.02.02.429358v1
Mouse models are critical in pre-clinical studies of cancer therapy, allowing dissection of mechanisms through chemical and genetic manipulations that are not feasible in the clinical setting. In studies of...
Great review of KRAS status based on smoking history.
Cancer and Metastasis Reviews (2020) 39:1159–1177
Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter
Source : https://www.mdpi.com/1422-0067/22/3/1137/htm
The promoter of the Kirsten ras (KRAS) proto-oncogene contains, upstream of the transcription start site, a quadruplex-forming motif called 32R with regulatory functions. As guanine under oxidative stress can be...
Biofunctional Peptide-Modified Extracellular Vesicles Enable Effective Intracellular Delivery via the Induction of Macropinocytosis
Source : https://www.mdpi.com/2227-9717/9/2/224
We previously reported that macropinocytosis (accompanied by actin reorganization, ruffling of the plasma membrane, and engulfment of large volumes of extracellular fluid) is an important process for the cellular uptake...