KRAS G12C-mutated advanced non-small cell lung cancer: a real-world cohort from the German prospective, observational, nation-wide CRISP Registry (AIO-TRK-0315)
Source : https://www.sciencedirect.com/science/article/pii/S0169500221000647
Available online 13 February 2021 * CRISP prospectively collected real-world data on advanced NSCLC and KRAS mutations * Of 1,039 patients, 39.5% had KRAS mutations, 38.9% of these were KRAS...
Targeting KRAS in Lung Cancer: The Past, Present, and Future | IASLC
Source : https://www.iaslc.org/iaslc-news/ilcn/targeting-kras-lung-cancer-past-present-and-future
Although RAS mutations constitute some of the most common genetic alterations in patients with adenocarcinomas, efforts to target the RAS oncoprotein have not proven fruitful, not only in NSCLC but...
Methylation of KRAS at lysine 182 and 184 by SETD7 promotes KRAS degradation | Meta
Source : https://www.meta.org/papers/methylation-of-kras-at-lysine-182-and-184-by/820196359
Oncogenic KRAS mutations are considered to be a key driver for initiation and progression in non-small-cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify KRAS...
Future perspectives from lung cancer pre-clinical models: new treatments are coming?
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815341/
Lung cancer currently stands out as both the most common and the most lethal type of cancer, the latter feature being partly explained by the fact that the majority of...