Treatment Patterns and Survival of Patients With Advanced Non-Small Cell Lung Cancer Guided by Comprehensive Genomic Profiling: Real-World Single-Institute Study in China - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33777783/

Although the National Comprehensive Cancer Network and the Chinese Society of Clinical Oncology guidelines recommend comprehensive genomic profiling of lung adenocarcinoma, it has not been widely applied in Chinese hospitals....

Second drug targeting KRASG12C shows benefit in mutated non-small-cell lung cancer

Source : https://www.eurekalert.org/pub_releases/2021-03/esfm-sdt032321.php

Clinical activity with a second drug inhibiting KRASG12C confirms its role as a therapeutic target in patients with advanced non-small-cell lung cancer (NSCLC) harbouring this mutation, according to results from...

Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33738287/

Lung cancer is the most common cancer worldwide and the leading cause of cancer-related deaths in both men and women. Despite the development of novel therapeutic interventions, the 5-year survival...

Targeting KRAS: The Elephant in the Room of Epithelial Cancers - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33777798/

Mutations of the proto-oncogene KRAS are the most frequent gain-of-function alterations found in cancer. KRAS is mutated in about 30% of all human tumors, but it could reach more than...

STK11 alterations in the pan-cancer setting: prognostic and therapeutic implications - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33744718/

Across cancers, STK11 alterations correlated with a poor prognosis regardless of therapy. However, STK11 alterations alone did not associate with inferior immunotherapy outcome in the pan-cancer setting or in NSCLC....