Scientists found that nine lipids were commonly dysregulated in patients with early-stage lung tumors. This study shows promise for the clinical detection of early-stage lung cancer in patients.
Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis
Source : https://www.science.org/doi/10.1126/scitranslmed.abk2756
Improving early detection of lung cancer is key to improving outcomes. On the basis of their exploratory single-cell RNA sequencing suggesting dysregulated lipid metabolism in early lung cancer tissue, Wang...
Comparative analysis and isoform-specific therapeutic vulnerabilities of KRAS mutations in non-small cell lung cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35091439/
doi: 10.1158/1078-0432.CCR-21-2719. Online ahead of print. 1 Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Harvard Medical School. 2 Department of Medical Oncology, Dana-Farber Cancer Institute. 3 Molecular Biotechnology...
Conclusions: This study demonstrates that KRAS isoforms are highly heterogeneous in terms of concurrent genomic alterations and gene expression profiles, and that stratification based on KRAS alleles should be considered in the design of future clinical trials.
Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35091470/
RAF inhibitors unexpectedly induce ERK signaling in normal and tumor cells with elevated RAS activity. Paradoxical activation is believed to be RAS dependent. In this study, we showed that LY3009120,...
Relevance: This study highlights the complexity of the allosteric RAF regulation by RAF inhibitors, and the importance of other RAS-related proteins in this process.
Phase I Trial of Definitive Concurrent Chemoradiotherapy and Trametinib for KRAS-Mutated Non-Small Cell Lung Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35051703/
doi: 10.1016/j.ctarc.2022.100514. Online ahead of print. 1 Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. Electronic address: [email protected]. 2 Department of Biostatistics, The...
Conclusions: The MTD for trametinib when combined with cCRT is 1.5 mg, with encouraging preliminary outcomes. This combination merits further study to combine with consolidation durvalumab in non-metastatic KRAS mutant NSCLC.
Impact of feature harmonization on radiogenomics analysis: Prediction of EGFR and KRAS mutations from non-small cell lung cancer PET/CT images - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35051856/
Our results demonstrated that regarding univariate modelling, while ComBat harmonization had generally a better impact on features for EGFR compared to KRAS status prediction, its effect is feature-dependent. Hence, no...
Conclusion: Our results demonstrated that regarding univariate modelling, while ComBat harmonization had generally a better impact on features for EGFR compared to KRAS status prediction, its effect is feature-dependent. Hence, no systematic effect was observed. Regarding the multivariate models, ComBat harmonization significantly improved the...