FDA Approves First Targeted Therapy for Lung Cancer Mutation Previously Considered Resistant to Drug Therapy
Today, the U.S. Food and Drug Administration approved Lumakras (sotorasib) as the first treatment for adult patients with non-small cell lung cancer whose tumors have a specific type of genetic...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • Sotorasib (Lumakras) is an inhibitor of the RAS GTPase family, and the first KRAS-targeted therapy to be approved by the FDA. This agent is indicated for adults with Show More
AMPKα loss promotes KRAS-mediated lung tumorigenesis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34040167/
AMP-activated protein kinase (AMPK) is a critical sensor of energy status that coordinates cell growth with energy balance. In non-small cell lung cancer (NSCLC) the role of AMPKα is controversial...
Circulating tumor DNA in advanced non-small-cell lung cancer patients with HIV is associated with shorter overall survival: Results from a Phase II trial (IFCT-1001 CHIVA) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34016488/
doi: 10.1016/j.lungcan.2021.05.013. Online ahead of print. 1 Oncology Thoracic Unit Pulmonology Department, AP-HP, Hôpital Cochin, F-75014, Paris, France; Université de Paris, Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Team...
Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33632153/
doi: 10.1186/s12885-021-07884-8. 1 Progenética, Grupo Pardini, Vespaziano, Brazil. [email protected]. 2 Research & Development Sector, Grupo Pardini, Vespaziano, Brazil. [email protected]. 3 Instituto COI de Educação e Pesquisa, Rio de Janeiro, Brazil....
Pleomorphic carcinoma of the lung: Prognostic models of semantic, radiomics and combined features from CT and PET/CT in 85 patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34041307/
In PCs of the lungs, the combined model leveraging semantic and radiomics features provides a better prognosis compared to using semantic and radiomics features separately. The high SUVmax of solid...