Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34111402/
Epithelial tissues are highly sensitive to anisotropies in mechanical force, with cells altering fundamental behaviors, such as cell adhesion, migration, and cell division. 1-5 It is well known that, in...
KRAS-dependent cancer cells promote survival by producing exosomes enriched in Survivin - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34111513/
Mutations in KRAS frequently occur in human cancer and are especially prevalent in pancreatic ductal adenocarcinoma (PDAC), where they have been shown to promote aggressive phenotypes. However, targeting this onco-protein...
Sotorasib is a selective irreversible inhibitor of the G12C-activated KRAS oncogene, present in approximately 13% of non–small-cell lung cancers. In a single-group, phase 2 trial involving 126 patients with previously treated KRAS –mutated NSCLC, 37% had a response.
https://www.nejm.org/doi/full/10.1056/NEJMoa2103695
Diagnostic testing companies should do a better job of turning around biomarker test results for lung cancer patients, according to a survey reported at the American Society of Clinical Oncology (ASCO) annual meeting.
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Oncologists urge faster biomarker results for lung cancer patients
Source : https://www.labpulse.com/index.aspx?sec=sup&sub=gen&pag=dis&ItemID=802127
Out of 170 clinicians polled, the vast majority (98%) said that they felt it was important to get biomarker test results back in from one to two weeks, but while...