The Prognostic Effect of KRAS Mutations in Non-Small Cell Lung Carcinoma Revisited: A Norwegian Multicentre Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34503114/
1 Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Technology and Science, N-7491 Trondheim, Norway. 2 Department of Pathology, St. Olav's Hospital, Trondheim University Hospital, N-7006 Trondheim, Norway....
Perspectives and Issues in the Assessment of SMARCA4 Deficiency in the Management of Lung Cancer Patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34440689/
Lung cancers are ranked third among the cancer incidence in France in the year 2020, with adenocarcinomas being the commonest sub-type out of ~85% of non-small cell lung carcinomas. The...
The KRAS-G12C inhibitor: activity and resistance - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34471232/
Although it has long been deemed "undruggable", with the development of drugs specifically binding the KRAS-G12C mutant protein, clinical trials that directly inhibit oncogenic RAS have recently made promising improvements....
The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34455214/
doi: 10.1016/j.lungcan.2021.08.005. Online ahead of print. 1 Queensland University of Technology, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Brisbane, Australia; Translational Research Institute, Brisbane, Australia; Institute for...
New study helps point the way toward developing personalized treatments distinct from those used for smokers’ cancers.
Study: Never-smokers' lung cancers genetically differ from smokers' tumors
esearchers have identified unique genetic signatures of lung cancer in people who never smoked cigarettes, using whole genome sequencing to analyze tumors from this under-studied population. The new study, published...