Severe Immune Checkpoint Inhibitor Hepatitis in KRAS G12C-Mutant NSCLC Potentially Triggered by Sotorasib: Case Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34590053/
Sotorasib is a first-in-class small molecule that irreversibly inhibits KRAS G12C, locking it in an inactive state, inhibiting oncogenic signaling, and inducing a proinflammatory microenvironment. Here, we report the first...
Available, FDA-approved drugs may be effective in targeting about 80% of never-smokers’ lung tumors
Most cases of never-smokers' lung cancer treatable with mutation-targeting drugs | Washington University School of Medicine in St. Louis
Visit the News Hub Available, FDA-approved drugs may be effective in targeting about 80% of never-smokers' lung tumors Washington University School of Medicine Despite smoking's well-known role in causing lung...
Cetuximab-siRNA Conjugate Linked Through Cationized Gelatin Knocks Down KRAS G12C Mutation in NSCLC Sensitizing the Cells Toward Gefitinib - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34542333/
Delivery of small-interfering RNA (siRNA) has been of great interest in the past decade for effective gene silencing. To overcome synthetic and regulatory challenges posed by nanoparticle-mediated siRNA delivery, antibody-siRNA...
-
KRAS Oncogene Connect4yrKey Points • Conclusion/Relevance: “While significant amount of work is required to enter clinical phase for the technology including formulation development, consistency batches, detailed physicochemical characterization, and in vivo efficacy studies, Show More
Sotorasib - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34554671/
No information is available on the clinical use of sotorasib during breastfeeding. Because sotorasib is 89% bound to plasma proteins, the amount in milk is likely to be low. However,...
KRAS G12C fragment screening renders new binding pockets - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34558391/
KRAS genes belong to the most frequently mutated family of oncogenes in cancer. The G12C mutation, found in a third of lung, half of colorectal and pancreatic cancer cases, is...