Primary Warthin's-like adenocarcinoma of the lung: A clinicopathological, immunohistochemical, and molecular analysis of three cases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34656914/
Three cases of primary pulmonary adenocarcinoma with prominent lymphoid stroma and papillary features mimicking Warthin's tumor are presented. The patients are two women and one man ages 52, 62, and...
Inactivation of AMPK leads to attenuation of antigen presentation and immune evasion in lung adenocarcinoma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34667030/
Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment...
The RXR Agonist MSU42011 Is Effective for the Treatment of Preclinical HER2+ Breast Cancer and Kras-Driven Lung Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34638488/
(1) Background: Notwithstanding numerous therapeutic advances, 176,000 deaths from breast and lung cancers will occur in the United States in 2021 alone. The tumor microenvironment and its modulation by drugs...
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KRAS Oncogene Connect4yrKey Points • Source: Cancers • Conclusion/Relevance: “In summary, the combination of MSU42011 plus anti-PD1 or anti-PDL1 antibodies was efficacious in reducing tumor number, tumor size, and burden in the A/J mouse model of Show More
Enhanced vulnerability of LKB1-deficient NSCLC to disruption of ATP pools and redox homeostasis by 8-Cl-Ado - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34654720/
Loss of function somatic mutations of STK11, a tumor suppressor gene encoding LKB1 that contributes to the altered metabolic phenotype of cancer cells, is the second most common event in...
Researchers Uncover New Findings about KRAS, an Important Protein in Cancer
Source : https://www.mskcc.org/news/researchers-uncover-new-findings-about-kras-important-protein
One of the most exciting advances in cancer treatment over the past few years has been the development of the drug sotorasib (Lumakras TM) for treating people with advanced non-small...