Selective elimination of immunosuppressive T cells in patients with multiple myeloma
Source : https://www.nature.com/articles/s41375-021-01172-x
Elimination of suppressive T cells may enable and enhance cancer immunotherapy. Here, we demonstrate that the cell membrane protein SLAMF7 was highly expressed on immunosuppressive CD8+CD28-CD57+ Tregs in multiple myeloma...
The Mitochondrial Protease LonP1 Promotes Proteasome Inhibitor Resistance in Multiple Myeloma
Source : https://www.mdpi.com/2072-6694/13/4/843
Multiple myeloma and its precursor plasma cell dyscrasias affect 3% of the elderly population in the US. Proteasome inhibitors are an essential part of several standard drug combinations used to...
Impact of depression on adherence to lenalidomide plus low-dose dexamethasone in patients with relapsed or refractory myeloma
Source : https://link.springer.com/article/10.1007/s00520-021-06017-y
Purpose While continued lenalidomide and low-dose dexamethasone (Rd) treatment could improve survival outcomes for multiple myeloma (MM), the association of depression on the adherence to Rd regimen in myeloma patients...
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Mark Fesler5yrAn interesting study linking mental health to long term medication adherence, an association that certainly makes clinical sense and an opportunity for providers in practice to screen for depression and Show More
Novel progresses of chimeric antigen receptor (CAR) T cell therapy in multiple myeloma
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867711/
Multiple myeloma (MM) is a malignant proliferative disease of plasma cells, which leads to suppressed hematopoietic and osteolytic diseases. Despite the use of traditional chemotherapy, hematopoietic stem cell transplantation (HSCT)...
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Mark Fesler5yrThis paper is a very nice review of chimeric antigen T cell therapy for multiple myeloma, and this therapy will likely become a major advance in the treatment of this Show More
Comparison of single and double autologous stem cell transplantation in multiple myeloma patients
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862995/
Autologous stem cell transplantation (ASCT) is one of the standard treatments of choice for eligible multiple myeloma (MM) patients. Herein, we aimed to analyze MM patients at our center and...
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Mark Fesler5yrWould caution drawing conclusions on this retrospective study as patients who received a double autoSCT may have had inferior survival simply related to biologically worse disease