Pembrolizumab plus pomalidomide and dexamethasone for relapsed or refractory multiple myeloma (KEYNOTE-183): subgroup analysis in Japanese patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33856638/
The global, randomized, open-label KEYNOTE-183 phase 3 study was closed early after an interim analysis showed unfavorable risk-benefit when pembrolizumab was added to pomalidomide and dexamethasone in patients with relapsed...
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Mark Fesler5yrSmall numbers in this retrospective analysis. At most hypothesis generating but seems unlikely that this will see additional work
Bleeding Diathesis in Multiple Myeloma: A Rare Presentation of a Dreadful Emergency With Management Nightmare - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33880309/
Multiple myeloma is a neoplastic disorder of plasma cells. An abnormal coagulation profile, though commonly seen in multiple myeloma, can rarely manifest as life-threatening hemorrhagic complications. Bleeding tendencies in multiple...
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Mark Fesler5yrThis is a case report of a very rare complication of a relatively common disease. Report reflects the fact that malignant hematologists sometimes have to work through complex benign hematological Show More
Dental pathologies in tumor patients with bone metastases or multiple myeloma scheduled for antiresorptive therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33880956/
doi: 10.2217/fon-2020-1240. Online ahead of print. 1 University Hospital for Cranio-Maxillofacial & Oral Surgery, A-6020, Innsbruck, Austria. 2 University Hospital for Dental Prosthetics & Restorative Dentistry, A-6020, Innsbruck, Austria. 3...
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Mark Fesler5yrThis article seems to reinforce the recommended practice to have patients obtain a baseline dental evaluation prior to bone antiresorptive therapy in myeloma given the high frequency of baseline issues Show More
SARS-CoV-2 Vaccines in Patients With Multiple Myeloma
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892292/
COVID-19 pandemic has led to an unprecedented need to develop an effective and safe vaccine in a timely manner. SARS-CoV-2 binds to human cells via the spike (S) protein, which...
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Mark Fesler5yrUnfortunately there is limited information on vaccine efficacy or aes in myeloma and other cancers but given the rates of severe illness, adherence to the current guidelines certainly makes sense Show More
tRNA-derived fragments and their roles in multiple myeloma | OTT
Multiple myeloma (MM) is the second most common hematological malignancy and is characterized by the accumulation of malignant plasma cells in the bone marrow. With the advent of new drugs,...
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Mark Fesler5yrInteresting area of research identifying rna sequences that may play a role in myeloma pathogenesis