DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33951891/
DIS3 gene mutations (DIS3mts) occur in roughly 10% of multiple myeloma (MM) patients; furthermore, DIS3 expression could be affected by monosomy 13 or del(13q), which occur in approximately 40% of...
Genetic Predictors of Mortality in Multiple Myeloma | TACG
Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of clonal plasma cells. The disease is virtually always preceded by an asymptomatic stage named monoclonal gammopathy of undetermined...
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Mark Fesler5yrThis article is a nice review of genetic abnormalities associated with myeloma, yet much remains to be learned about the mechanisms of progression and varying rates of such complications
Synergistic interaction between HDAC and MCL-1 inhibitors through downregulation of BCL-XL in multiple myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33910332/
doi: 10.3324/haematol.2020.277152. Online ahead of print. 1 Department of Medicine I, Wilhelminen Cancer Research Institute, Clinic Ottakring, Vienna, Austria; Recipient of a DOC Fellowship of the Austrian Academy of Sciences...
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Mark Fesler5yrWill be interesting to see if this bench research on myeloma cell lines can be translated into a clinically useful combination strategy at the bedside
Impact of depression on adherence to lenalidomide plus low-dose dexamethasone in patients with relapsed or refractory myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33575840/
Patients with depression had a substantially high risk of poor adherence compared to patients without depression. Given that Rd treatment is mainly offered by outpatient clinics, active interventions to reduce...
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Mark Fesler5yrVery important topic linking compliance and ultimately effectiveness of oral antineoplastic therapy with depression
Clinical outcomes and complications of surgical interventions for multiple myeloma lesions in the extremities and pelvis: A retrospective clinical study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33847579/
Objective: This study aimed to assess the pain and functional status of patients who underwent various surgical interventions for the stabilization of selected multiple myeloma (MM) lesions in the extremities...
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Mark Fesler5yrLocation rather than the disease seems to best reflect the outcome of surgical intervention for skeletal related cancer complications