Impact of depression on adherence to lenalidomide plus low-dose dexamethasone in patients with relapsed or refractory myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33575840/
Patients with depression had a substantially high risk of poor adherence compared to patients without depression. Given that Rd treatment is mainly offered by outpatient clinics, active interventions to reduce...
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Mark Fesler4yrVery important topic linking compliance and ultimately effectiveness of oral antineoplastic therapy with depression
Clinical outcomes and complications of surgical interventions for multiple myeloma lesions in the extremities and pelvis: A retrospective clinical study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33847579/
Objective: This study aimed to assess the pain and functional status of patients who underwent various surgical interventions for the stabilization of selected multiple myeloma (MM) lesions in the extremities...
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Mark Fesler4yrLocation rather than the disease seems to best reflect the outcome of surgical intervention for skeletal related cancer complications
Pembrolizumab plus pomalidomide and dexamethasone for relapsed or refractory multiple myeloma (KEYNOTE-183): subgroup analysis in Japanese patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33856638/
The global, randomized, open-label KEYNOTE-183 phase 3 study was closed early after an interim analysis showed unfavorable risk-benefit when pembrolizumab was added to pomalidomide and dexamethasone in patients with relapsed...
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Mark Fesler4yrSmall numbers in this retrospective analysis. At most hypothesis generating but seems unlikely that this will see additional work
Bleeding Diathesis in Multiple Myeloma: A Rare Presentation of a Dreadful Emergency With Management Nightmare - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33880309/
Multiple myeloma is a neoplastic disorder of plasma cells. An abnormal coagulation profile, though commonly seen in multiple myeloma, can rarely manifest as life-threatening hemorrhagic complications. Bleeding tendencies in multiple...
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Mark Fesler4yrThis is a case report of a very rare complication of a relatively common disease. Report reflects the fact that malignant hematologists sometimes have to work through complex benign hematological Show More
Dental pathologies in tumor patients with bone metastases or multiple myeloma scheduled for antiresorptive therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33880956/
doi: 10.2217/fon-2020-1240. Online ahead of print. 1 University Hospital for Cranio-Maxillofacial & Oral Surgery, A-6020, Innsbruck, Austria. 2 University Hospital for Dental Prosthetics & Restorative Dentistry, A-6020, Innsbruck, Austria. 3...
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Mark Fesler4yrThis article seems to reinforce the recommended practice to have patients obtain a baseline dental evaluation prior to bone antiresorptive therapy in myeloma given the high frequency of baseline issues Show More